grant
Tumor Suppressor Protein, p53
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025AcetylationActive Follow-upAdenocarcinoma CellAdenocarcinoma of the EsophagusAffectAmyloidosisAnimal ModelAnimal Models and Related StudiesAntioncogene Protein p53ApoptosisApoptosis PathwayApoptoticBasal Transcription FactorBasal transcription factor genesBasic Mechanisms of SUMOylationBindingBiochemicalBiologicalBiophysicsBiotinC-terminalCD 6 antigenCD6CD6 antigenCancersCell BodyCell Culture TechniquesCell Cycle ArrestCellsCellular StressCellular Stress ResponseCellular Tumor Antigen P53Cellular biologyChronicCollaborationsCollectionColon CancerColon CarcinomaColon NeoplasmsColon TumorColonic MassColonic NeoplasmsColonic TumorColorectal CancerCysteineDNADNA Binding DomainDNA DamageDNA Damage RepairDNA InjuryDNA RepairDNA mutationDNA-Binding Protein MotifsDeoxyribonucleic AcidE1A Binding Protein p300EP300EP300 geneEPEGEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEposideEsophageal AdenocarcinomaEtoposideExhibitsGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenerationsGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGoalsGrowthHalf-CystineHeat ShockHeat-Shock ReactionHeat-Shock ResponseHeterograftHeterologous TransplantationHigh Throughput AssayHumanHydroxylationHypoxiaHypoxicImmune PrecipitationImmune infiltratesImmunoprecipitationInflammatoryIntermediary MetabolismInvadedItalyKAT3BL-CysteineLaboratoriesLastetLower GI TractLower Gastrointestinal TractMCF-7MCF-7 CellMCF-7DRMCF-7WTMCF7MCF7 cellMacrophageMalignant CellMalignant Glandular CellMalignant NeoplasmsMalignant TumorMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasuresMediatingMetabolicMetabolic ProcessesMetabolismMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethylationModern ManModificationMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMucosaMucosal TissueMucous MembraneMutationMφN-terminalNH2-terminalNeoplasm MetastasisNuclear ExtractNuclear ProteinsOncogenesisOncogenicOncoprotein p53Oxygen DeficiencyP53PeptidesPermeabilityPhosphoprotein P53Phosphoprotein pp53PhosphorylationPoint MutationPopulationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrognosisProgrammed Cell DeathProtein ModificationProtein PhosphorylationProtein TP53ProteinsPublishingRNA ExpressionReactionRegulationReportingResearchRoleRomeSUMOylationSecondary NeoplasmSecondary TumorSpeedwellStimulusStressSumoylation PathwayTP53TP53 geneTRP53Tissue GrowthTransactivationTranscriptionTranscription ActivationTranscription ActivatorTranscription CoactivatorTranscription Factor CoactivatorTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ActivationTranscriptional Activator/CoactivatorTumor PromotionTumor Protein p53Tumor Protein p53 GeneTumor Suppressor ProteinsUbiquitilationUbiquitinationUbiquitinoylationUniversitiesUnscheduled DNA SynthesisVepesidVeronicaVitamin HXenograftXenograft procedureXenotransplantationactive followupamyloid diseaseanti-cancer treatmentbiologicbiophysical foundationbiophysical principlesbiophysical sciencescancer cellcancer in the coloncancer metastasiscancer microenvironmentcancer progenitorcancer progenitor cellscancer progressioncancer stem cellcancer stem like cellcell biologycell culturecell culturescell stresscoenzyme Rcofactorcolon neoplasiaconformationconformationalconformational stateconformationallyconformationsepigeneticallyexperimentexperimental researchexperimental studyexperimentsfollow upfollow-upfollowed upfollowupgain of functiongenome mutationhigh throughput screeninghistone acetyltransferase p300immune cell infiltrateimprovedin vivoinhibitormalignancymalignant progenitormalignant stem cellmetabolic profilemodel of animalmutantneoplasm progressionneoplasm/cancerneoplastic progressionnoveloncogenic progenitoroncogenic stem cellsontogenyp300p53 Antigenp53 Genesp53 Tumor Suppressorpeptide mimeticpeptide mimicpeptidomimeticspre-clinicalpreclinicalpreferenceprogenitor cell migrationprogenitor like cancer cellprogenitor migrationprotein p53responsesenescencesenescentsimulationsmall moleculesocial rolestem cell migrationstem like cancer celltherapeutic targettherapeutically effectivetrans-activationtranscription factortumortumor cell metastasistumor microenvironmenttumor progressiontumor suppressortumorigenesisubiquinationubiquitin conjugationxeno-transplantxeno-transplantation
Description preview
The p53 tumor suppressor protein is a key component of the cellular response to stress. It is a homo-tetrameric, sequence-specific transcription factor activated by DNA damage, hypoxia, heat shock, and other types of stress and regulates DNA repair, cell cycle arrest, senescence, metabolism and apoptosis. It is maintained at low levels in…
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