grant
Tumor and immune determinants of effective anti-tumor immunity in renal cell carcinoma
NIHUS FederalResearch GrantFY20259p21.3AddressAdvanced CancerAdvanced Malignant NeoplasmApoptosisApoptosis PathwayCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell CommunicationCell FunctionCell InteractionCell PhysiologyCell ProcessCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeCheckpoint inhibitorChromosomal DeletionChromosome DeletionClear cell renal cell carcinomaClinicalCollaborationsCryofixationCryopreservationDNA mutationDataDeathDetectionDiseaseDisorderFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesGene AlterationGene MutationGene TranscriptionGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGrawitz TumorHypernephroid CarcinomaHypernephromaImmuneImmune checkpoint inhibitorImmune infiltratesImmune responseImmunesImmunofluorescenceImmunofluorescence ImmunologicImmunogenomicsImmunomodulationImmunosuppressionImmunosuppression EffectImmunosuppressive EffectImmunotherapeutic agentIn SituKidney CancerKidney CarcinomaKnowledgeMacrophageMalignant CellMediatingMediatorMedicineMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMethodsModelingMutationMφNatureNeoplasm MetastasisNephroid CarcinomaPD-1 checkpoint pathwayPD-1 pathwayPD-1 signaling pathwayPD1 checkpoint pathwayPD1 pathwayPD1 signaling pathwayPartial MonosomyPatientsPhenotypePopulationPrimary NeoplasmPrimary TumorProbabilistic ModelsProbability ModelsProductionPrognosisProgrammed Cell DeathProliferatingPublic HealthRNA ExpressionRNA SeqRNA sequencingRNAseqRecurrenceRecurrentRenal AdenocarcinomaRenal CancerRenal CarcinomaRenal Cell AdenocarcinomaRenal Cell CancerRenal Cell CarcinomaResearch SpecimenResistanceRoleSecondary NeoplasmSecondary TumorSolid NeoplasmSolid TumorSpecimenStatistical ModelsStromal CellsSubcellular ProcessT cell infiltrationT-CellsT-LymphocyteT8 CellsT8 LymphocytesTherapeutically TargetableTranscriptionTumor BurdenTumor ImmunityTumor LoadUnited StatesValidationWorkadvanced diseaseadvanced illnessanti programmed cell death protein 1 checkpoint pathwayanti programmed cell death protein 1 pathwayanti programmed cell death protein 1 signaling pathwayanti-tumor immunityantitumor immunitycancer cellcancer immunitycancer infiltrating T cellscancer metastasiscancer microenvironmentccRCCclinical translationclinically translatablecohortcold preservationcold storagecopy number alterationcytokineexhaustexome sequencingexome-seqflow cytophotometrygene defectgenome mutationgenomic datagenomic datasethigh dimensionalityhost responseimmune cell infiltrateimmune check point inhibitorimmune drugsimmune microenvironmentimmune modulationimmune regulationimmune suppressionimmune suppressive activityimmune suppressive functionimmune suppressive macrophagesimmune system responseimmune-based therapeuticsimmunogenicimmunologic reactivity controlimmunologic therapeuticsimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressive activityimmunosuppressive functionimmunosuppressive macrophagesimmunosuppressive microenvironmentimmunosuppressive responseimmunosuppressive tumor microenvironmentimmunotherapeuticsimmunotherapy agentindustrial partnershipindustry partnerindustry partnershipkidney adenocarcinomamutant alleleneo-antigenneo-epitopesneoantigensneoepitopesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpharmacologicresistance to therapyresistantresistant to therapyresponseresponse to therapyresponse to treatmentscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestatistical linear mixed modelsstatistical linear modelstherapeutic resistancetherapeutic responsetherapy resistanttherapy responsethymus derived lymphocytetranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment resistancetreatment responsetreatment responsivenesstumortumor cell metastasistumor immune microenvironmenttumor infiltrating T cellstumor microenvironmenttumor-immune system interactionsvalidations
Description preview
PROJECT SUMMARY
Immune checkpoint inhibitors (ICIs) targeting the PD-1 pathway have transformed the management of many
advanced cancers, including renal cell carcinoma (RCC), but most patients do not receive durable benefit from
these treatments. Whereas many efforts to understand ICI response and resistance in other tumor types have
often focused…
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