grant
Tubular Hypertrophy and AKI Susceptibility in Diabetes
NIHUS FederalResearch GrantFY20263' Untranslated Regions3'UTRAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAffectAnimalsAutophagocytosisBindingCell BodyCell Communication and SignalingCell DeathCell Death InductionCell SignalingCellsChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalDataDeath RateDegradation PathwayDegradative PathwayDiabetes MellitusDialysisDialysis procedureDown-RegulationER stressESKDESRDEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEngineeringExhibitsFaceGenesGeneticGoalsHypertrophyImpairmentIncidenceIntracellular Communication and SignalingIschemiaKO miceKidneyKidney TubulesKidney Urinary SystemKinasesKnock-out MiceKnockout MiceLeadMediatingMetabolic Protein DegradationMiceMice MammalsMolecularMolecular InteractionMolecular TargetMurineMusNephronsNull MouseOutcomePathway interactionsPatientsPb elementPhosphorylation SitePhosphotransferase GenePhosphotransferasesPlayPositionPositioning AttributePredispositionPreventivePrognosisProtein BiosynthesisProtein TurnoverProteinsProximal Kidney TubulesRegulatory Protein DegradationRenal tubule structureReperfusion TherapyReportingResearchRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein S6Ribosomal Protein SynthesisRiskRoleSchemeSeveritiesSignal TransductionSignal Transduction SystemsSignalingSiteSurvivorsSusceptibilityTestingTherapeuticTransgenic MiceTransphosphorylasesTubularTubular formationUriniferous TubeWorkacute kidney injuryautophagybiological adaptation to stressbiological signal transductionchronic kidney diseaseco-morbidco-morbiditycomorbiditydetermine efficacydiabetesdiabeticdiabetic patientdialysis therapyefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationendoplasmic reticulum stressevaluate efficacyexamine efficacyfacesfacialheavy metal Pbheavy metal leadimprovedinhibitorinsoluble aggregateischemia injuryischemic injurymortality ratenecrocytosisnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-diabeticnondiabeticnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetpathwaypharmacologicpreventpreventingprotein aggregateprotein aggregationprotein degradationprotein synthesispublic health relevancereaction; crisisrenalrenal proximal tubulerenal tubulereperfusionresponsesocial rolestress responsestress; reactiontype 1 and type 2 diabetestype I and type II diabetes
Description preview
PROJECT SUMMARY
Despite advances in treatment, acute kidney injury (AKI) patients requiring dialysis still face a high
mortality rate of 50-60%, and survivors have a 28-fold increased risk of progressing to chronic kidney disease
(CKD), leading to end-stage renal disease (ESRD). Diabetic patients are particularly susceptible to AKI and
suffer…
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