grant
Triglycerides, Diabetes and Cardiovascular Disease
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 15 Aug 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025ANGPT5ANGPTL3ANGPTL3 geneASCVDAddressAdult-Onset Diabetes MellitusApolipoproteinsAreaArterial Fatty StreakAtherogenicityAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseBioinformatics coreBioinformatics research coreBioinformatics resource coreBiological MarkersBlood PlasmaBrittle Diabetes MellitusCardiovascular DiseasesCell BodyCellsCholesterolComplementComplement ProteinsComplications of Diabetes MellitusD-GlucoseDevelopmentDextroseDiabetes ComplicationsDiabetes MellitusDiabetes-Related ComplicationsDiabetic AngiopathiesDiabetic ComplicationsDiabetic Vascular ComplicationsDiabetic Vascular DiseasesDiabetic Vascular DisorderDoctor of PhilosophyEicosapentaenoic AcidEndothelial CellsEndotheliumEnsureFatty LiverFertilizationFundingGlucoseGoalsHepaticHumanHyperglyceridemiaHypertriglyceridemiaIDDMIndividualInflammationInsulin-Dependent Diabetes MellitusIntermediary MetabolismInterruptionInvestigationInvestigatorsJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusKineticsKnowledgeLDL CholesterolLDL Cholesterol LipoproteinsLDL ReceptorsLDLR geneLesionLinkLipidsLipolysisLipoprotein LDL ReceptorsLipoproteinsLiver SteatosisLow Density Lipoprotein CholesterolLow Density Lipoprotein ReceptorMaturity-Onset Diabetes MellitusMetabolicMetabolic ProcessesMetabolismMethodologyMethodsMiceMice MammalsModern ManMurineMusMyeloid CellsNIDDMNatureNew YorkNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusP01 MechanismP01 ProgramPathogenesisPathway interactionsPatientsPh.D.PhDPlasmaPlasma SerumPopulationPre-Clinical ModelPreclinical ModelsPrediabetesPrediabetes syndromePrediabetic StateProductionProductivityProgram Project GrantProgram Research Project GrantsProteinsProteomicsRaised TGRaised triglyceridesResearchResearch PersonnelResearch Program ProjectsResearchersResidualResidual stateReticuloendothelial System, Serum, PlasmaRiskRisk FactorsSR-B proteinsSlow-Onset Diabetes MellitusStable Diabetes MellitusSteatohepatitisSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTREM2TREM2 geneTechniquesTestingTherapeuticTherapeutic AgentsTherapeutic InterventionTimnodonic AcidTriacylglycerolTriggering Receptor Expressed in Myeloid Cells 2Triggering Receptor Expressed on Myeloid Cells 2Triglyceride MetabolismTriglyceridesType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesUniversitiesWashingtonadult onset diabetesanalytical toolangiopoietin 5angiopoietin-like 3atheromatosisatherosclerosis plaqueatherosclerosis riskatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic riskatherosclerotic vascular diseasebeta-Lipoprotein Cholesterolbio-markersbiologic markerbiomarkercardiovascular disease riskcardiovascular disordercardiovascular disorder riskclass B scavenger receptorscomplementationcritical perioddesigndesigningdevelopmentaldiabetesdiabetic cardiomyopathydiabetic cardiopathydiabetic cardiopathy diseasediabetic cardiopathy disorderdiabetic cardiovascular diseasediabetic cardiovascular disorderdyslipoproteinemiaeffective interventioneicosapentanoic acidelevated tgelevated triglyceridefertilizationshepatic inflammationhepatic steatosishepatosteatosishigh triglyceridesincreased triglyceridesinflamed liverinsightinsulin dependent diabetesinsulin dependent type 1intervention therapyjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabetesliver inflammationmaturity onset diabetesmicrovascular complications of diabetesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyparticlepathwaypharmacologicplaques in atherosclerosispre-diabetespre-diabeticprediabeticprematureprematuritypreventpreventingprogramssynergismtooltype 1 and type 2 diabetestype 2 DMtype I and type II diabetestype I diabetestype II DMtype one diabetestype two diabetesuptakevascular inflammation
Description preview
The overall hypothesis of the Triglycerides, Diabetes and Cardiovascular Disease Program Project for the
next 5 years is that that abnormal assembly, secretion, composition and clearance of TRLs promotes
the accumulation of highly atherogenic RLPs in atherosclerotic lesions in individuals with T2D, and
that RLPs contribute to CVD risk by altering…
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