grant
Treatment of chronic venous thrombosis with histotripsy and thrombolytics
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 15 Dec 2017Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AblationAcuteAddressAdjuvantAffectAgeAlgorithmsAmericanAmerican Heart AssociationAnimalsAntithrombotic AgentsAntithrombotic DrugsAutomobile DrivingBlood CirculationBlood PlateletsBlood VesselsBloodstreamBody TissuesChronicClinicClinicalClinical EvaluationClinical TestingClinical TrialsClottingCoagulationCoagulation ProcessCombined Modality TherapyDataDeep Vein ThrombosisDeep-Venous ThrombosisDevelopmentDiseaseDisorderEchographyEchotomographyElectronicsElementsEmbolization TherapyEmbolotherapyEngineeringEnsureFibrinolysesFibrinolysisFibrinolytic AgentsFibrinolytic DrugsFibrinolytic TherapyFluoroscopyGeometryHealth Care CostsHealth CostsHemoglobinHepatic NeoplasmsHeterogeneityHourHumanImageIn VitroIndividualInterventional radiologyLengthLiver neoplasmsMarrow plateletMeasurementMechanicsMedical UltrasoundMicrofluidicsModern ManMonitorMultimodal TherapyMultimodal TreatmentOutcomePathologyPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPhasePhlebothrombosisPhysiologic pulsePlatelet ActivationPlateletsProtocolProtocols documentationPublic HealthPulseRecommendationResearch SpecimenResistanceRuptureSafetySalineSaline SolutionSchemeSocietiesSourceSpecimenStructureSystemTechniquesTestingTherapeutic EmbolizationTherapeutic ThrombolysisThrombocytesThrombolytic AgentsThrombolytic DrugsThrombolytic TherapyThrombosisThrombusTimeTissuesTransducersTransmissionTreatment ProtocolsTreatment RegimenTreatment ScheduleTreatment outcomeUltrasonic ImagingUltrasonic TherapyUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUpdateVeinsVenousVenous ThrombosisWorkagedagesantithrombotic medicationantithromboticsclinical testcombination therapycombined modality treatmentcombined treatmentcustomized therapycustomized treatmentdesigndesigningdevelopmentaldiagnostic ultrasounddrivingeffective therapyeffective treatmentelectronicelectronic deviceembolizationhemodynamicshepatic neoplasiahepatic neoplasmhepatic tumorimage guidanceimage guidedimagingimaging biomarkerimaging markerimaging probeimaging-based biological markerimaging-based biomarkerimaging-based markerimproved outcomein vivoindividualized medicineindividualized patient treatmentindividualized therapeutic strategyindividualized therapyindividualized treatmentinstrumentationliver tumormechanicmechanicalmulti-modal therapymulti-modal treatmentpathwaypatient oriented outcomespatient specific therapiespatient specific treatmentpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpig modelpiglet modelporcine modelprototyperesearch clinical testingresistantsafety assessmentscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsonogramsonographysound measurementstandard of careswine modeltailored medical treatmenttailored therapytailored treatmenttherapeutic ultrasoundthromboticthrombotic diseasethrombotic disordertransmission processtreatment strategyultrasonic treatmentultrasound based therapyultrasound guided therapyultrasound imagingultrasound scanningultrasound therapyultrasound treatmentunique treatmentvascularµfluidic
Description preview
Summary: Deep vein thrombosis (DVT) is a major public health problem that affects 640,000 Americans each
year, and accrues $10B in healthcare costs. For critical thromboses, the American Heart Association and
Society for Interventional Radiology recommend thrombolytic drugs be administered to break down the
thrombus and restore flow in the vessel.…
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