grant
TR&D3
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 16 May 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAlgorithmsAnimal ExperimentsAnimal ModelAnimal Models and Related StudiesAnimalsArchitectureArtifactsAutopsyBehaviorBiological FunctionBiological ProcessBody TissuesBuffersCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessClinicalCollectionComplexComputational toolkitComputer softwareDataData SetDecision MakingDescriptorDevelopmentDimensionsDiseaseDisorderDrugsDysfunctionEngineering / ArchitectureFeedbackFunctional disorderGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingHeartHumanIlluminationImageImage AnalysesImage AnalysisImage EnhancementIn VitroIndividualIndividual DifferencesIntracellular Communication and SignalingInvestigatorsLeadLeannessLearningLightingLinkMachine LearningMeasurementMedicationMessenger RNAMethodsModelingModern ManMolecularMolecular AnalysisMolecular FingerprintingMolecular ProfilingMonitorMorphologic artifactsMorphologyMotionMovementNoiseOptical reporterOpticsOrganOutcomes ResearchPathologyPatternPb elementPeristalsisPharmaceutical PreparationsPhasePhotobleachingPhototoxicityPhysiologicPhysiologicalPhysiopathologyProcessPropertyProteinsProtocolProtocols documentationProviderResearchResearch PersonnelResearchersResolutionRespirationScanningSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSoftwareSpeedStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationStreamStructureSubcellular ProcessThickThicknessThinnessTimeTissue imagingTissuesTrainingTranscript Expression AnalysesTranscript Expression AnalysisTreatment EfficacyUncertaintyVisualizationWorkanalysis pipelineanalyze gene expressionanimal experimentbiological signal transductionbiological systemsbiomedical imagingbody movementcell behaviorcell imagingcellular behaviorcellular imagingclinical validationcohortcomputational pipelinescomputational toolboxcomputational toolscomputational toolsetcomputerized toolsde-noisingdeep learningdeep learning algorithmdeep learning methoddeep learning strategydenoisingdetermine efficacydevelopmentaldigitaldigital pathologydoubtdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationendomicroscopyendomicrosopeevaluate efficacyexamine efficacyexperienceexperimental animalexperimental animalsfeature extractionfield based datafield learningfield studyfield testfluorescence imagingfluorescent imaginggene expression analysisgene expression assayheavy metal Pbheavy metal leadhigh dimensionalityhuman subjectimage evaluationimage interpretationimage processingimagingimaging Segmentationimaging in vivoimaging systemimprovedin vivoin vivo fluorescence imagingin vivo imagingin-vivo fluorescence imaginginsightintervention efficacylive cell imagelive cell imaginglive cellular imagelive cellular imagingmRNAmRNA Expressionmachine based learningmachine learning based modelmachine learning modelmicroendoscopemicroendoscopymicrosystemsmodel of animalmolecular profilemolecular signaturenecropsynew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyopticaloptoacoustic imagingparallel computationparallel computerparallel computingpathophysiologyphotoacoustic imagingpoint of carepostmortempreventpreventingprospectiveprotein expressionquantitative imagingreal time modelreal-time imagesrealtime imagerealtime modelresolutionsrespiratory mechanismsensorstatistical analysissynergismtemporal measurementtemporal resolutiontherapeutic efficacytherapy efficacythree dimensionaltime measurementtooltranscriptional profilingtumor
Description preview
D Cai and K Najarian will serve as Project Lead and co-Lead, respectively, for TRD3. Live fluorescence
imaging is challenged by high levels of autofluorescence background and potential for photobleaching and
phototoxicity. Faster frame rates are needed to capture subtle cellular behaviors, but an increase in imaging
speed may result in a reduction…
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