grant
Transport Processes and Nervous System Function
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY20253-D3-D modeling3-Dimensional3D3D modelingAddressAffectAnatomic SitesAnatomic structuresAnatomyAnisotropyAntimitotic AgentsAntimitotic DrugsAntimitoticsApoplexyAreaAttentionAxonBasal CellBiologicalBiological MarkersBiophysical ProcessBiophysicsBlood flowBody TissuesBrainBrain CancerBrain Nervous SystemBrain Vascular AccidentBrain regionCategoriesCell BodyCell Communication and SignalingCell Culture TechniquesCell DeathCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCell divisionCell membraneCellLineCellsCellular ExpansionCellular FunctionCellular GrowthCellular Metabolic ProcessCellular PhysiologyCellular ProcessCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCharacteristicsClinicalClinical TreatmentComplexCoupledCytoplasmic MembraneD-GlucoseDWI (diffusion weighted imaging)DWI-MRIDataData CompressionDepositDepositionDepressed moodDevelopmentDevicesDextroseDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingElectric ConductivityElectrical ConductivityElectrodesElectromagnetic FieldsElectromagnetic Fields RadiationElectromagneticsElementsEncephalonEnvironmentEpilepsyEpileptic SeizuresEpilepticsExhibitsExudateFrequenciesFunctional MRIFunctional Magnetic Resonance ImagingGlioblastomaGlucoseGoalsGrade IV Astrocytic NeoplasmGrade IV Astrocytic TumorGrade IV AstrocytomaHeterogeneityHot SpotHydrogen OxideIn SituIn VitroIntracellular Communication and SignalingIonsKnowledgeLengthLinkLocationMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMagnetismMajor Depressive DisorderMalignant Tumor of the BrainMalignant neoplasm of brainMapsMeasurableMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMembraneMethodologyMethodsMicroscopicMicroscopyMicrotubular Function InhibitorsMigraineMigraine HeadacheMitosis Inhibitor AgentsMitosis Inhibitor DrugsMitosis InhibitorsMitotic Inhibitor AgentsMitotic Inhibitor DrugsMitotic InhibitorsMitotic spindleModelingMolecular TransportMotionNIMHNINDSNMR ImagingNMR TomographyNational Institute of Mental HealthNational Institute of Neurological Diseases and StrokeNational Institute of Neurological Disorders and StrokeNerve CellsNerve UnitNervous SystemNervous System PhysiologyNeural CellNeurocyteNeurologicNeurologic Body SystemNeurologic Organ SystemNeurologic functionNeurologicalNeurological functionNeuronsNeurosciencesNuclear Magnetic Resonance ImagingO elementO2 elementOrganellesOrganismOsmotic PressureOxygenParentsPatternPhase TransitionPhysicsPhysiologyPlasma MembranePopulationProcessProxyPublishingPumpRelaxationReporterResearchResearch ActivitySafetyScalpScalp structureSeizure DisorderSignal TransductionSignal Transduction SystemsSignalingSliceStimulusStrains Cell LinesStreamStrokeStructureSubcellular ProcessSystemTechniquesTemperatureTestingTheoretical StudiesTherapeuticTherapeutic UsesTimeTissuesTranscranial magnetic stimulationTransport ProcessTumor CellVisitWaterWater MovementsWorkZeugmatographybio-markersbiologicbiologic markerbiological signal transductionbiomarkerbiophysical foundationbiophysical mechanismbiophysical principlesbiophysical sciencesblood oxygen level dependentblood oxygenation level dependentbrain attackcell culturecell culturescell growthcell metabolismcellular metabaolismcerebral vascular accidentcerebrovascular accidentclinical applicabilityclinical applicationclinical depressionclinical interventionclinical therapycompression algorithmcultured cell linedMRIdaughter celldensitydepresseddeprivationdevelopmentaldiffuseddiffusesdiffusingdiffusion tensor imagingdiffusionselectric fieldelectrical conductanceepilepsiaepileptogenicexperimentexperimental researchexperimental studyexperimentsfMRIfallsfluid flowglioblastoma multiformeimprovedin vivoinsightinstrumentinterestliving systemmagneticmagnetic fieldmajor depressionmajor depression disordermembrane structurenecrocytosisneoplastic cellnervous system functionneuralneural stimulationneuronalnew technologynovelnovel technologiesparentplasmalemmaresponsesadnesssoundspongioblastoma multiformestrokedstrokestheoriesthree dimensionalthree-dimensional modelingtissue culturetrial regimentrial treatmentwater flowwater monitoringwater quality monitoringwater testing
Description preview
We have been investigating several biophysical mechanisms possibly associated with neuronal excitation which also may be feasible to measure and map in vivo using MRI. Having successfully constructed and tested an experimental system to interrogate organotypic cultured brain cortical slices using diffusion and other forms of MR, we showed that the…
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