grant
Translational Project
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 17 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAnti-viral AgentsAssayAu antigenAustralia AntigenB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood SerumBody TissuesCell BodyCellsChimeraChimera organismChromosomesChronicChronic Hepatitis BCircular DNAClassificationClinicalCollaborationsCpG IslandsCpG-Rich IslandsDNADNA IntegrationDNA mutationData SetDeoxyribonucleic AcidEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsExtremitiesFeedbackGene TranscriptionGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomicsGenotypeGeographyGoalsHBVHBV X proteinHBV cureHBV functional cureHBV infected individualsHBV infection in patientsHBV infection in peopleHBV patientsHBeAgHBsAgHBxHBxAgHIVHIV and HBVHIV and hepatitis BHIV-HBVHIV/HBVHIV/hepatitis BHIV/hepatitis B virusHepatic CellsHepatic Parenchymal CellHepatitis B Surface AntigensHepatitis B VirusHepatitis B Virus-XHepatitis B X-ProteinHepatitis B e AntigensHepatitis Be AntigensHepatocarcinomaHepatocellular CarcinomaHepatocellular cancerHepatocyteHepatomaHost FactorHost Factor ProteinHumanHuman Immunodeficiency VirusesHybridsIFNImmunologyIn SituIndividualInfectionInformaticsIntegration Host FactorsInterferonsInterruptionIslandLAV-HTLV-IIILimb structureLimbsLinkLiverLiver CellsLiver Cells CarcinomaLymphadenopathy-Associated VirusMaintenanceMapsMessenger RNAModern ManMolecularMutationNHP modelsNon-Polyadenylated RNANon-TrunkOutcomePathogenesisPersonsPhenotypePrimary carcinoma of the liver cellsRNARNA ExpressionRNA Gene ProductsRNA SeqRNA sequencingRNAseqResidualResidual stateRibonucleic AcidSerumSystematicsT-CellsT-LymphocyteTestingTimeTissuesTranscriptTranscriptionTranscription ActivationTranscriptional ActivationTranscriptional ControlTranscriptional RegulationTransgenic OrganismsViralViral GenomeVirus AssemblyVirus-HIVWorkanaloganti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsarmburden of infectionchimeraschronic HBV infectionchronic hepatitis B infectionchronic hepatitis B virus infectionchronic infections with hepatitis B viruschronically infected with HBVchronically infected with hepatitis Bcircular RNAclinical relevanceclinically relevantclosed circular RNAco-infectioncoinfectionddPCRdroplet digital PCRdroplet digital Polymerase Chain Reactiondroplet-based digital PCRend stage liver diseaseend stage liver failureepigeneticallygenome mutationhepatic body systemhepatic organ systemhepatitis B curehepatitis B functional curehepatitis B patientshepatitis B virus X antigenhepatitis B virus X proteinhepatitis B virus and human immunodeficiency virushepatitis B virus curehepatitis B virus functional curehepatitis B virus infected individualshepatitis B virus infection in patientshepatitis B virus infection in peoplein vivoindexingindividuals with HBVindividuals with hepatitis Binfection burdenintrahepaticlaser capture microdissectionliver carcinomalong read seqlong-read sequencinglong-read transcript sequencingmRNAmethylation testingmultiomicsmultiple omicsnano porenanoporenonhuman primate modelsnovelnovel viruspanomicspatients with HBVpatients with hepatitis Bpeople with HBVpeople with hepatitis Bperipheral bloodpotential biological markerpotential biomarkerquorum sensingresponsesingle moleculespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsthymus derived lymphocytetooltranscriptional transactivator hbxtranscriptome sequencingtranscriptomic sequencingtransgenictranslational goaltranslational missionviral DNAviral RNAviral assemblyvirologyvirus DNAvirus RNAvirus genome
Description preview
Hepatitis B virus (HBV) infects 300 million people chronically and is the leading cause of end-stage liver
disease and hepatocellular carcinoma, outcomes which are worse in the ~10% of people with HIV who also
have chronic hepatitis B. Thus, finding an HBV cure, which requires loss of hepatitis B surface antigen
(HBsAg), is urgently needed for…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click