grant

Translational Immunopsychiatry Unit

Organization NATIONAL INSTITUTE OF MENTAL HEALTHLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Abnormal MovementsAffectAge of OnsetAlpha-Beta-Omega Interferon Receptor-1Amino Acid SequenceAmmon HornAntibodiesAntibody RepertoireAntipsychotic AgentsAntipsychotic DrugsAntipsychoticsAntiviral Protein Alpha TypeAreaAssayAuditory HallucinationAutoantibodiesAutoimmuneAutoimmune StatusAutoimmune encephalitisAutoimmune encephalopathyAutoimmunityAutopsyAwardB-cell receptor repertoire sequencingB-cell receptor sequencingBCR repertoire sequencingBCR seqBCR sequencingBCRseqBacteriaBacteriophage T7Basic ResearchBasic ScienceBehaviorBindingBioassayBiological AssayBiological MarkersBlood - brain barrier anatomyBlood CellsBlood PlasmaBlood SampleBlood specimenBlood-Brain BarrierBrainBrain DiseasesBrain DisordersBrain InflammationBrain Nervous SystemCancersCatatoniaCell BodyCell LineCellLineCellsCerebrospinal FluidChildhoodChildren's HospitalClinicalClinical ResearchClinical StudyCodeCoding SystemCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalColiphage T7CollaborationsCollectionCornu AmmonisDataData DisplayDelusionsDendritesDevelopment and ResearchDiagnosisDiseaseDisorderDisturbance in cognitionDown SyndromeDrugsDyskinesia SyndromesDyskinesiasDyskinetic syndromeEncephalitisEncephalonEncephalon DiseasesEnterobacteria phage T7EvaluationFocal Neurologic DeficitsFundingGenerationsGenesGoalsHealthHemato-Encephalic BarrierHippocampusHortega cellHuIFN-Alpha-RecHumanHuman CloningIFNBRIFRCImmuneImmune PrecipitationImmunesImmunologic FactorsImmunologic ModelImmunologic SubtypingImmunological FactorsImmunological ModelsImmunophenotypingImmunoprecipitationImpaired cognitionIndividualIndividuals with down syndromeInfectionInterferon Alpha-Beta Receptor Alpha ChainInterviewIntracranial CNS DisordersIntracranial Central Nervous System DisordersInvestigatorsLangdon Down syndromeLos AngelesMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMajor Depressive DisorderMajor TranquilizersMajor Tranquilizing AgentsMalignant NeoplasmsMalignant TumorManiasManicManic StateMeasurementMeasuresMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicationMedicineMemory DeficitMemory impairmentMental DepressionMental disordersMental health disordersMicrogliaModern ManMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMongolismMovement Disorder SyndromesMovement DisordersMusculoskeletal Pain DisorderN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNHGRINIMHNMDA Receptor-Ionophore ComplexNMDA ReceptorsNMR ImagingNMR TomographyNational Center for Human Genome ResearchNational Human Genome Research InstituteNational Institute of Mental HealthNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocyteNeuroleptic AgentsNeuroleptic DrugsNeurolepticsNeuronsNuclear Magnetic Resonance ImagingObsessive-Compulsive DisorderObsessive-Compulsive NeurosisPANDASParasitesPatientsPatternPediatric Acute-Onset Neuropsychiatric SyndromePediatric Autoimmune Neuropsychiatric DisorderPediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus InfectionsPediatric HospitalsPeptidesPerceptionPeripheral Blood CellPhage DisplayPharmaceutical PreparationsPhasePhenotypePlasmaPlasma SerumPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary Protein StructureProtein ArrayProtein ModificationProtein SecretionProteinsPsychiatric DiagnosisPsychiatric DiseasePsychiatric DisorderPsychosesPublishingR & DR&DReceptor GeneReportingResearchResearch ActivityResearch PersonnelResearchersReticuloendothelial System, Serum, PlasmaRheumatic DiseasesRheumatismRheumatologic DiseasesRheumatologic DisorderSchizoaffective DisordersSchizophreniaSchizophrenic DisordersSeizuresShapesSiteStandardizationStrains Cell LinesStreptococcusSymptomsSystemT cell receptor repertoire sequencingT cell receptor sequencingT7 PhageTCR repertoire sequencingTCR sequencingTCR-seqTCRseqTestingTranslational Research EnterpriseTrisomy 21United States National Institutes of HealthValidationVariantVariationVirusVisual HallucinationWomanWorkZeugmatographyantibody based diagnosticantibody diagnosticautoimmune antibodyautoreactive antibodybench bed sidebench bedsidebench to bed sidebench to bedsidebench to clinicbench to clinical practicebio-informatics pipelinebio-markersbiobankbioinformatics pipelinebiologic markerbiomarkerbiorepositorybloodbrain barriercerebral spinal fluidchromosome 21 trisomychromosome 21 trisomy syndromeclinical depressionclinical diagnosticsclinical phenotypecognitive dysfunctioncognitive losscohortcollegecollegiateconformationconformationalconformational stateconformationallyconformationscongenital acromicria syndromecultured cell linedementia praecoxdepressiondifferential expressiondifferentially expresseddown syndrome individualsdown syndrome patientsdrug/agentfungusgitter cellhippocampalhuman subjectiPSiPSCiPSCsifnar1 gene productimmunologic substanceimmunological substanceimprovedindexinginduced pluripotent cellinduced pluripotent stem cellinduced pluripotent stem cells derived from patientsinduced pluripotent stem cells from patientsinducible pluripotent cellinducible pluripotent stem cellinterestmajor depressionmajor depression disordermalignancymedical diagnosticmemory dysfunctionmental illnessmesogliamicroglial cellmicrogliocytemorbus Downmultiomicsmultiple omicsnano-luciferasenanoluciferasenecropsyneoplasm/cancerneural imagingneural inflammationneuro-imagingneuroimagingneuroinflammationneuroinflammatoryneurological imagingneuronalneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatrynew approachesnovelnovel approachesnovel strategiesnovel strategypanomicspatient derived human iPSpatient derived human iPSCpatient derived human induced pluripotent stem cellpatient derived iPSpatient derived iPSCpatient derived induced pluripotent cellspatient derived induced pluripotent stem cellspatient-derived pluripotent stem cellspatients with down syndromepediatricpediatric acute neuropsychiatric syndromepeople with down syndromeperivascular glial cellpostmortemprogramsprospectiveprotein sequencepseudohypertrophic progressive muscular dystrophypsychiatric illnesspsychiatric symptompsychological disorderpsychoticresearch and developmentresponsescRNA sequencingscRNA-seqschizophrenia spectrumschizophrenia spectrum disorderschizophrenicself reactive antibodyseropositivesingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspinal fluidsuicide victimtechnology platformtechnology systemtranscriptional differencestranslation research enterprisetranslational goaltranslational missiontranslational research programtrisomy 21 syndrometype I IFN receptortype I interferon receptorvalidations
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The Translational Immunopsychiatry Unit (TIU) is an integrated clinical, basic, and translational research program that identifies, characterizes, and models immunologic factors that causally contribute to neuropsychiatric illness.

In the past year, the TIU deployed its ~1.8 million peptide T7 bacteriophage display platform (PanSeq, whereby ~930K…

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