grant
Transfer RNAs as novel mediators in acute lung injury
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026ARDSAcute Lung InjuryAcute Pulmonary InjuryAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAdvisory CommitteesAwardBacterial InfectionsBioinformaticsBiologicalBiological FunctionBiological MarkersBiological ProcessBiologyBody TissuesCardiac DiseasesCardiac DisordersCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCell DeathCell FunctionCell PhysiologyCell ProcessCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCellular modelCessation of lifeClinicalCognitiveComplexCritical CareCritical IllnessCritically IllDa Nang LungDataDeathDiffuseDiseaseDisorderDrug TherapyEC 2.1.1EC 2.1.1.31-36EndotoxinsEnsureEnvironmentExperimental ModelsFamilyFoundationsFunctional RNAFundingFutureGene TranscriptionGenetic TranscriptionGuanineHealth Care UtilizationHeart DiseasesHost DefenseHost Defense MechanismHost resistanceHumanImmunologyImmunomodulationIn VitroIndividualInfectionInflammasomeInflammatoryInjuryK-AwardsK-Series Research Career ProgramsKO miceKnock-out MiceKnockout MiceLiquid substanceLungLung InflammationLung Respiratory SystemLung Tissue FibrosisLung damageMacrophageMediatorMedicineMentorsMentorshipMessenger RNAMetabolic stressMethylationMethyltransferaseMicroRNAsModelingModern ManModificationMolecular and Cellular BiologyMyelogenousMyeloidMφNon-Polyadenylated RNANoncoding RNANontranslated RNANull MouseOhioOxidative StressP aeruginosaP. aeruginosaPBMCParentsPathogenesisPatientsPeripheral Blood Mononuclear CellPharmacological TreatmentPharmacotherapyPhysiciansPhysiologicPhysiologicalPneumoniaPneumonitisPrincipal InvestigatorProteinsPseudomonas aeruginosaPseudomonas pyocyaneaPulmonary FibrosisPulmonary InflammationQOLQuality of lifeRNARNA ExpressionRNA Gene ProductsRNA MethylasesRNA SeqRNA StabilityRNA sequencingRNA, Transfer, MethyltransferasesRNAseqRegulationResearchResearch Career ProgramRibonucleic AcidRoleSamplingScientistShock LungSignaling MoleculeSleepSourceSpecificityStiff lungStressSubcellular ProcessSurvivorsSyndromeT RNA MethyltransferasesTask ForcesTestingTissuesTrainingTranscriptionTransfer RNATranslationsTriplet Codon-Amino Acid AdaptorUniversitiesUntranslated RNAUpregulationWorkadvisory teambacteria infectionbacterial diseasebio-markersbiologicbiologic markerbiomarkercareercareer developmentcell stressdrug interventiondrug treatmentexperiencefibrosis in the lungfluidglobal gene expressionglobal transcription profilehealth care service usehealth care service utilizationheart disorderhuman diseaseimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunopathologyimmunoregulationimmunoregulatoryinflammatory lung diseaseinhibitorinjuriesinjury to tissueinsightliquidlung fibrosislung injurymRNAmethylasemiRNAmicrobialmouse modelmurine modelnecrocytosisnew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnoncodingnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetparentpathogenpharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsposttranscriptionalpreservationpreventpreventingprofessorprogramspsychologicpsychologicalpulmonarypulmonary damagepulmonary injurypulmonary tissue damagepulmonary tissue injuryrespiratoryskillssocial rolestressorsuccesstRNAtRNA Methyltransferasestissue injurytranscriptometranscriptome sequencingtranscriptomic sequencingtransfer Ribonucleic acidstranslationtranslational cliniciantranslational physiciantranslational progresstranslational progressiontranslational studytransmethylasewet lung
Description preview
ABSTRACT
This application, “Transfer RNAs as novel mediators in acute lung injury,” is submitted by Joseph S. Bednash,
MD for a K08 Mentored Clinical Scientist Research Career Development Award. I am a physician-scientist in the
Division of Pulmonary, Critical Care and Sleep Medicine at the Ohio State University (OSU). I am applying for
this…
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