grant
Transcriptional regulation of mitochondrial metabolism in human intestinal stem cells
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 May 2025Deadline 31 Mar 2030
NIHUS FederalResearch GrantFY2026Abnormal Assessment of MetabolismAffectAllelesAllelomorphsAmericanAreaAssayAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBioassayBiological AssayBiologyBiomedical EngineeringBody TissuesCRISPRCRISPR/Cas systemCell BodyCell Communication and SignalingCell CycleCell Division CycleCell FunctionCell LineCell PhysiologyCell ProcessCell SignalingCellLineCellsCellular FunctionCellular PhysiologyCellular ProcessChIP SequencingChIP-seqChIPseqChromatinClustered Regularly Interspaced Short Palindromic RepeatsColitisCombining SiteCommunitiesData BasesDatabasesDevelopmentDifferential Gene ExpressionDiseaseDisorderDoctor of PhilosophyEpithelial CellsEpitheliumEventFKHRFKHR-Like 1FKHRL1FOXO1FOXO1AFOXO1A geneFOXO3FOXO3AFOXO3A geneFactor AnalysesFactor AnalysisForkhead Box O1AForkhead Box O3AForkhead in RhabdomyosarcomaForkhead in Rhabdomyosarcoma-Like 1FundingFutureGI Stem cellGene ExpressionGene TranscriptionGene Transfer TechniquesGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic TranscriptionGenomicsGoalsHealthHomeHomeostasisHumanImpaired tissue repairImpaired wound healingIn VitroIncidenceIndividualInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderIntermediary MetabolismIntestinalIntestinal DiseasesIntestinal DisorderIntestinesIntracellular Communication and SignalingInvestigatorsKnock-outKnockoutLinkMediatingMentorsMetabolicMetabolic PathwayMetabolic ProcessesMetabolic StudiesMetabolismMetabolism StudiesMiceMice MammalsMichiganMitochondriaModern ManMolecular InteractionMurineMusNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNorth CarolinaPathologyPatientsPh.D.PhDPhenotypePhysiological HomeostasisPublic HealthRNA ExpressionReactive SiteRecombinant DNA TechnologyRegulationRepressionResearchResearch PersonnelResearchersRespirationSeveritiesSignal TransductionSignal Transduction SystemsSignalingSodium Dextran SulfateStrains Cell LinesSubcellular ProcessTestingTherapeuticTimeTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionTissuesTrainingTranscriptionTranscription Factor Proto-OncogeneTranscription InitiationTranscription factor genesTranscriptional ControlTranscriptional RegulationTransgenesisUnited StatesUniversitiesWorkabnormal tissue repairbio-engineeredbio-engineersbioengineeringbiological engineeringbiological signal transductionbowelcandidate identificationcell engineeringcellular engineeringchip modelchip systemchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcompare to controlcomparison controlcostcultured cell linedata basedelayed wound healingdevelopmentalenthusiastic atmosphereenthusiastic environmentgain of functiongastrointestinalgastrointestinal stem cellgenetically engineeredgenetically engineered cellsgenetically modified cellsgut progenitorgut stem cellhomesin vivoinflammatory disease of the intestineinflammatory disorder of the intestineinhibitorinnovateinnovationinnovativeintestinal autoinflammationintestinal epitheliumintestinal progenitorintestinal stem cellsintestine diseaseintestine disorderloss of functionmembermetabolic abnormality assessmentmetabolism measurementmetabolomicsmetabonomicsmitochondrialmitochondrial dysfunctionmitochondrial metabolismnext generationnovelon a chipon chipoverexpressoverexpressionpreventpreventingprogramspromoterpromotorrespiratory mechanismsupportive atmospheresupportive environmenttranscription factortranscriptomics
Description preview
PROJECT SUMMARY
Dr. Joseph Burclaff, PhD is mentored by Dr. Scott Magness, PhD at the University of North Carolina at
Chapel Hill. UNC receives the 6th highest federal research funding of any American university and is home to
the NIDDK-sponsored Center for Gastrointestinal Biology and Disease with a vibrant research community. The
CGIBD and Dr.…
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