grant
Transcriptional Regulation of Antibody Responses and Immunity
Organization UNIVERSITY OF ARIZONALocation TUCSON, UNITED STATESPosted 24 Sept 2012Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAb responseAb-mediated immunityAb-mediated protectionAblationAdjuvantAntibodiesAntibody FormationAntibody ProductionAntibody ResponseAntibody immunityAntibody protectionAntibody-mediated protectionAntigensAwardB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBioinformaticsBlood Plasma CellCOVID-19 virusCOVID19 virusCell BodyCellsClinical ResearchClinical StudyCoV-2CoV2DataEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpistasisEpistatic DeviationEventFamily memberFundingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneticGenetic EpistasisGenetic TranscriptionGerminal CenterGoalsGrippeHumanHumoral ImmunitiesImmunityImmunizationInfectionInfluenzaInteraction DeviationJapanese B Encephalitis VirusJapanese encephalitis virusKnock-outKnockoutLengthLength of LifeLongevityMapsMemory B CellMemory B-LymphocyteMiceMice MammalsModelingModern ManModernizationMolecularMurineMusNaturePathway interactionsPatternPlasma CellsPlasmacytesRNA ExpressionRouteSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Structure of germinal center of lymph nodeTestingTimeTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationVaccinationWorkWuhan coronavirusantibody biosynthesisantibody-based immunityantibody-mediated immunitycoronavirus disease 2019 viruscoronavirus disease-19 virusepigeneticallyepistatic interactionepistatic relationshipexperimentexperimental researchexperimental studyexperimentsgene manipulationgene x gene interactiongenetic epistasesgenetic manipulationgenetically manipulategenetically perturbhCoV19immunogenimmunoglobulin biosynthesisimprintin vivolife spanlifespannCoV2pathogenpathwayplasmocyteprogramsresponsescATAC sequencingscATAC-seqscRNA sequencingscRNA-seqsensorsingle cell ATAC-seqsingle cell ATAC-sequencingsingle cell Assay for Transposase Accessible Chromatin sequencingsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell sequencing assay for transposase accessible chromatinsingle cell transcriptomic profilingsingle-cell Assay for Transposase-Accessible Chromatin with sequencingsingle-cell RNA sequencingsingle-cell assay for transposase-accessible chromatin using sequencingsingle-cell assay for transposase-accessible chromatin-seqtooltranscription factor
Description preview
ABSTRACT
The duration of antibody-mediated immunity varies widely with the specific immunization or infection for
reasons that remain difficult to understand or predict. The specific features of molecular circuitry in B cells and
plasma cells that are responsible for these differences have still not been defined. In this application, which…
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