grant
Transcriptional Mechanisms that Catalyze Dysregulated Type 17 Mucosal Inflammation via Innate Lymphoid Cells
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026AddressAffectAmericanAreaArthritisAtrophic ArthritisAutoimmune DiseasesAutoregulationBasal Transcription FactorBasal transcription factor genesBioinformaticsBiologyBiometricsBiometryBiostatisticsBody TissuesCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCaliforniaCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCell Communication and SignalingCell CountCell Growth and MaintenanceCell MaintenanceCell NumberCell SignalingCellsChromatinChronicClinicalClinical ResearchClinical StudyComputational BiologyControl GroupsCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDevelopmentDiseaseDisorderDisseminated SclerosisEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumEventFosteringFoundationsFundingGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGenetic TranscriptionHealthHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHepatobiliaryHomeostasisIL-17IL-17 GeneIL-17AIL-17A GeneIL-22IL17IL17 ProteinIL17 geneIL17AIL17A GeneImmuneImmune responseImmunesImmunobiologyImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologyImmunomodulationImmunophysiologyImmunosuppressed HostInducer CellsInducer T-LymphocytesInflammationInflammatoryInflammatory Bowel DiseasesInflammatory Bowel DisorderInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17InterventionIntestinalIntestinal MucosaIntestinesIntracellular Communication and SignalingJointsK-AwardsK-Series Research Career ProgramsKI miceKidneyKidney Urinary SystemKnock-in MouseKnowledgeLupusLymphatic cellLymphocyteLymphocyticLymphoidLymphoid CellMaintenanceMapsMasksMediatingMentorsMentorshipMiceMice MammalsModelingMolecularMucosaMucosal InflammationMucosal TissueMucositisMucous MembraneMultiple SclerosisMurineMusPathogenicityPathologyPathway interactionsPatientsPhenocopyPhysiciansPhysiologicPhysiologicalPhysiological HomeostasisPlayPopulationProcessProductionProliferatingPsoriasis ArthropathicaPsoriatic ArthritisPublic HealthRNA ExpressionResearchResearch Career ProgramResearch TrainingRheumatoid ArthritisRoleSan FranciscoScientistSignal TransductionSignal Transduction SystemsSignalingSiteSkinSmall IntestinesSpecialtyStimulusStructureT-CellsT-LymphocyteTherapeuticTissuesTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationUniversitiesarthriticautoimmune conditionautoimmune disorderautoimmunity diseasebalancebalance functionbiological signal transductionbowelbowel inflammationcareercell typechronic inflammatory diseasecomputer biologycytokinedevelop therapydevelopmentalepigeneticallyepigenomicsgastrointestinalglobal healthgut inflammationhost responsehuman diseaseimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimmunosuppressed patientimprovedin vivoinflamed bowelinflamed gutinflamed intestineinflammatory disease of the intestineinflammatory disorder of the intestineinsightinsular sclerosisinterleukin-22intervention developmentintestinal autoinflammationintestinal inflammationknockin micelymph cellmedical specialtiesmouse modelmultidisciplinarymurine modelmutantnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetp65pathwaypreventpreventingprogramsrenalrheumatic arthritisskillssmall bowelsocial rolesocietal coststherapy developmentthymus derived lymphocytetranscription factortranscriptomicstransdifferentiationtreatment development
Description preview
Chronic inflammatory diseases, such as inflammatory bowel disease, psoriatic arthritis, and lupus, impose a
significant public health burden. Despite our understanding of type 17 immune responses, the mechanisms by
which aberrant type 17 inflammation is triggered and sustained remain unclear. Given the critical role of group
3 innate lymphoid…
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