grant
Transcriptional inactivation of the CNS HIV reservoir with Tat-targeting lipid nanoparticles.
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 15 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AIDS VirusARV resistanceARV resistantAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAnti-retroviral resistanceAnti-viral AgentsAntibodiesAssayBindingBioassayBiological AssayBody TissuesBrainBrain InflammationBrain Nervous SystemCNS Nervous SystemCNS infectionCRISPRCRISPR/Cas systemCannabinoidsCell BodyCell NucleusCellsCentral Nervous SystemCentral Nervous System InfectionsCentral Nervous System Infectious DiseaseCentral Nervous System Infectious DisorderChronicCirculatory CollapseClinicalClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsComplexDrug TargetingEncephalitisEncephalonExhibitsFormulationGene ExpressionGene TargetingGene TranscriptionGenetic TranscriptionHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV neurocognitive impairmentHIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-associated neurocognitive disorderHTLV-III InfectionsHTLV-III-LAV InfectionsHortega cellHumanHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsImmune systemIn VitroIncidenceInfectionInjectionsInterruptionLAV-HTLV-IIILaboratoriesLinkLymphadenopathy-Associated VirusMacacaMacaqueMessenger RNAMiceMice MammalsMicrogliaModelingModern ManMolecularMolecular InteractionMurineMusNeuraxisNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NucleusPathogenesisPersonsPlayPopulationProvirusesRNA ExpressionResidualResidual stateRoleSIVSamplingShockSimian Immunodeficiency VirusesSingle-Nucleus SequencingSolidSurfaceTestingTissuesToxic effectToxicitiesTrans-Activation of Transcription ProteinTrans-Activator of Transcription of HIVTransactivating Regulatory ProteinTranscriptionViralViral BurdenViral Gene ProductsViral Gene ProteinsViral GenesViral InactivationViral LoadViral Load resultViral ProteinsViral reservoirVirusVirus InactivationVirus reservoirVirus-HIVanti-retroviral resistantanti-viral compoundanti-viral drugsanti-viral medicationanti-viral therapeuticanti-viralsantiretroviral therapyantiretroviral treatmentbrain cellchallenge in rhesus macaquescirculatory shockco-morbidco-morbiditycomorbiditygitter cellhumanized micehumanized mouseiPSiPSCiPSCsimmune clearanceimmune eliminationin vivoinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaqueslipid based nanoparticlelipid nanoparticlemRNAmesogliamicroglial cellmicrogliocytemouse modelmurine modelnovelpathogenicity geneperivascular glial cellpreventpreventingresistance to ARVresistance to anti-retroviralresistant to ARVresistant to anti-retroviralrhesus challengerhesus macaque challengerhesus monkey infectionsNuc-Seqshockssingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqskillssnRNA sequencingsnRNA-seqsocial rolesuccesssystemic inflammationsystemic inflammatory responsetat Genestat Proteintoolviral RNAvirulence genevirulent genevirus RNAvirus protein
Description preview
Project Summary:
Despite the success of antiretroviral therapy (ART), HIV remains an incurable infection, due to the presence of
a persistent viral reservoir that is resistant to ART. This reservoir is widely disseminated throughout the body,
including in solid tissues such as the central nervous system (CNS) where microglial cells constitute the…
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