grant
Transcriptional Coordination and Gene Regulation by MED12 in the Cardiomyocyte
Organization OHIO STATE UNIVERSITYLocation Columbus, UNITED STATESPosted 1 Jul 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY20253C-based approach3C-based assay3C-based method3C-based strategy3C-based technique3C-based technologyArchitectureAssayAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayCREBCREB1CREB1 geneCalciumCardiacCardiac DiseasesCardiac DisordersCardiac Muscle CellsCardiac MyocytesCardiocyteCell BodyCellsChIP SequencingChIP-seqChIPseqChromatinComplexCoupledDNA mutationDNA-Dependent RNA Polymerase IIDataDevelopmentDiseaseDisorderEngineering / ArchitectureExclusion ChromatographyGel ChromatographyGel FiltrationGel Filtration ChromatographyGel Permeation ChromatographyGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic ModelsGenetic TranscriptionGenetic defectGenetic mutationGenomicsGoalsHeartHeart DiseasesHeart Muscle CellsHeart failureHeart myocyteHomeostasisHumanIndividualKinasesKnock-outKnockoutLinkMacromolecular Protein ComplexesMediatingMediatorMiceMice MammalsMissense MutationModelingModern ManMolecularMolecular InteractionMultiprotein ComplexesMurineMusMutationPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPopulationProteinsPublishingRNA ExpressionRNA Polymerase BRNA Polymerase IIRNA SeqRNA sequencingRNAseqReporterReporter GenesReportingRepressionRoleSerum Response FactorTestingTherapeuticTranscriptionTranscription Factor Proto-OncogeneTranscription Factor SRFTranscription RepressorTranscription factor genesTranscriptional ControlTranscriptional RegulationTranscriptional RepressorTransgenic MiceTransgenic ModelTransgenic OrganismsTransphosphorylasesWorkc-fos Serum Response FactorcAMP Response Element-Binding Protein 1cardiac failurecardiac functioncardiomyocytechromatin conformation capturechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchromosome capturechromosome conformation captureclinical relevanceclinically relevantcohesindevelopmentalexperimentexperimental researchexperimental studyexperimentsfunction of the heartgenetic repressorgenome mutationheart disorderheart functionhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsinduced human pluripotent stem cellsinsightmissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmortalitynoveloverexpressoverexpressionprogramssocial roletranscription factortranscriptome sequencingtranscriptomic sequencingtransgenictransgenic trait
Description preview
Heart disease is the leading cause of mortality worldwide and disruption of transcription in cardiomyocytes (CMs) contributes to the progression of heart disease. Transcriptional regulation of some individual genes by transcription factors (TFs) is described. However, much less is known about how functionally related genes, or gene expression…
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