grant
Transcriptional control of endocardial-specific gene expression
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Dec 2024Deadline 30 Nov 2028
NIHUS FederalResearch GrantFY202621+ years oldATAC sequencingATAC-seqATACseqAbscissionAddressAdultAdult HumanAffectArteriesAssay for Transposase-Accessible Chromatin using sequencingAutoregulationBar CodesBasal Transcription FactorBasal transcription factor genesBindingBiochemicalBrachydanio rerioCardiacCardiac DiseasesCardiac DisordersCardiac MalformationCardiac Muscle CellsCardiac MyocytesCardiac developmentCardiocyteCardiovascular DiseasesCell BodyCell Communication and SignalingCell CycleCell Division CycleCell IsolationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCellsChromatinCis TestsDanio rerioDefectDevelopmentDevelopmental ProcessDiseaseDisorderDistalEndocardiumEndothelial CellsEndotheliumEnhancersExcisionExtirpationGene Action RegulationGene ActivationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGene Transfer TechniquesGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic ProcessesGenetic TranscriptionGenomeGrowthHeartHeart DiseasesHeart InjuriesHeart MalformationHeart Muscle CellsHeart myocyteHomeostasisHypoplastic Left Heart SyndromeHypoplastic Left VentricleInjuryInterrupted Aortic ArchInterventricular SeptumIntracellular Communication and SignalingKnock-outKnockoutLarvaLive BirthLymphatic EndotheliumMammaliaMammalsMesenchymalMiceMice MammalsMolecularMolecular InteractionMorbidityMurineMusMyocardialOrganismPathway interactionsPhysiological HomeostasisPlayProcessRNA ExpressionRegulationRemovalReporterResearchRoleSignal TransductionSignal Transduction SystemsSignalingSiteSourceSpecific qualifier valueSpecificitySpecifiedStressSurgical RemovalTestingThyroid Gland HormoneThyroid HormonesTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransgenesisTransgenic MiceTransgenic OrganismsVenousVentricularVentricular septumWorkZebra DanioZebra FishZebrafishabnormal heart developmentadulthoodassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbarcodebiological signal transductioncardiac injurycardiac regenerationcardiac repaircardiogenesiscardiomyocytecardiovascular disordercell sortingcell typecis acting elementcohortcompare to controlcomparison controlcongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationdevelopmentalgene regulatory networkgenetic approachgenetic strategyheart developmentheart disorderheart formationheart regenerationheart repairhypoplastic left hearthypoplastic left syndromein vivoinjuredinjuriesinjury responseinsightliving systemmortalityneonatal micenovelontogenypathwayregeneration potentialregenerative potentialresectionresponseresponse to injurysensorsocial roletooltranscription factortransgenicunpublished works
Description preview
SUMMARY
Congenital heart disease (CHD) is a significant cause of morbidity and mortality worldwide, affecting nearly 1%
of all live births, and there is a critical need to understand the cellular and molecular processes that control
normal heart development and to understand how dysregulation of those processes leads to CHD. Beyond the
burden of…
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