grant
Transcriptional Control During Erythropoiesis
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 16 Sept 2013Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAnemiaAssayAutomobile DrivingB-thalassemiaBasal Transcription FactorBasal transcription factor genesBindingBioassayBiological AssayBlood Precursor CellBlood erythrocyteCausalityCell BodyCell CountCell FunctionCell NumberCell PhysiologyCell ProcessCell Surface ProteinsCellsCellular FunctionCellular PhysiologyCellular ProcessChromatinChromatin Remodeling ComplexChromatin Remodeling FactorComplexComputer AnalysisDataData SetDevelopmentDiseaseDisorderEnhancersErythrocytesErythrocyticErythroidErythroid CellsErythropoiesisEtiologyEventGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic TranscriptionGenomeGenomicsGoalsHealthHematopoieticHematopoietic Progenitor CellsHematopoietic stem cellsHemoglobinHumanHybridsISWIISWI proteinImitation SwitchImmunodeficient MouseJointsKnowledgeMapsMarrow erythrocyteMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMeasurementMeasuresMessenger RNAMethodsMissionModalityModelingModern ManMolecular InteractionMonitorNational Institutes of HealthNatureNuclearOutcomePatientsPopulationProcessProductionProgenitor CellsProteinsProteomeProteomicsProxyPublic HealthRNA ExpressionReactionRed Blood CellsRed CellRegulationResearchRoleSubcellular ProcessSystemTechnologyTestingTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTransplantationUnited States National Institutes of HealthValidationWorkantagonismantagonistbeta Thalassemiablood cell progenitorblood corpusclesblood progenitorblood stem cellblood-forming stem cellcausationchromatin modifierchromatin remodelingcofactorcomputational analysescomputational analysiscomputer analysesdesigndesigningdevelopmentaldisease causationdosagedrivingerythroid developmentgene locusgene regulatory networkgenetic locusgenome analysisgenome scalegenome-widegenomewidegenomic locationgenomic locusglobal gene expressionglobal transcription profilehematopoietic progenitorhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellhigh definitionhigh-resolutionhuman modelin vivoinnovateinnovationinnovativeinsightknock-downknockdownmRNAmodel of humannetwork modelsnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachp-Thalassemiaprogenitorprogramspromoterpromotorprotein protein interactionrecruitsocial rolestem cellsthree dimensionaltranscription factortranscriptometransplantvalidationsβ-thalassemia
Description preview
Erythropoiesis is a dynamic process governed by quantitative changes in the relative levels of transcription fac-
tors (TFs) that control gene regulatory networks (GRNs). Recently, we generated the first high-resolution GRNs
of human erythropoiesis that integrate chromatin accessibility, transcripts, and cell surface proteins, all measured…
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