grant
Transcriptional Co-Regulators in Epidermis
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Aug 1998Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY202521+ years oldATAC sequencingATAC-seqATACseqAbbreviationsAddressAdultAdult HumanAgingAssay for Transposase-Accessible Chromatin using sequencingAtopic DermatitisAtopic EczemaAtopic NeurodermatitisBasal CellBasal Transcription FactorBasal transcription factor genesBindingBioinformaticsCUT&RUNCell BodyCell DifferentiationCell Differentiation processCell NucleusCell to Cell Communication and SignalingCell-Cell SignalingCellsChromatinCleavage Targets and Release Using NucleaseCleavage Under Targets and Release Using NucleaseCollaborationsComputer ModelsComputerized ModelsCutaneous DisorderDNA mutationDataDermatosesDevelopmentDisseminated NeurodermatitisEmbryoEmbryonicEpidermisFISH TechnicFISH TechniqueFISH analysisFISH assayFluorescence Activated Cell Sorting FractionationFluorescence In Situ HybridizationFluorescence-Activated Cell SortingFluorescence-Activated Cell SortingsFluorescent in Situ HybridizationGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomic approachGlycolysisGrantGranular LayerHistoryHumanHyperkeratosis Palmaris et PlantarisImpairmentKO miceKeratosis Palmaris et PlantarisKnock-out MiceKnockout MiceLightMalignant Skin NeoplasmMapsMathMath ModelsMathematicsMethodsMiceMice MammalsModelingModern ManMolecular InteractionMorphologyMurineMusMutateMutationNatureNuclearNuclear RNANucleusNull MouseOntologyPalmoplantar KeratodermaPalmoplantar KeratosisPhenotypePhotoradiationPopulationProgenitor CellsProteinsPsoriasisRNA ExpressionRNA SeqRNA sequencingRNAseqRecording of previous eventsRegulationResearchRoleSignal PathwaySkinSkin CancerSkin DiseasesSkin Diseases and ManifestationsSortingStratum GranulosumSystems BiologyTestingTranscriptTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranslationsWorkadulthoodallergic dermatitisallergic eczemaassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbio-informatics toolbioinformatics toolcellular differentiationcomputational modelingcomputational modelscomputer based modelscomputerized modelingcornificationcutaneous diseasedermal diseasedermal disorderdevelopmentalexperimentexperimental researchexperimental studyexperimentsgene regulatory networkgenome mutationgenomic effortgenomic strategyhistone modificationhistoriesinnovateinnovationinnovativeinsightintercellular communicationkeratinizationkeratinocyteloricrinmalignant skin tumormathematic modelmathematical modelmathematical modelingpostnatalprogramspsoriasiformpsoriaticscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell genomicssingle cell transcriptomic profilingsingle-cell RNA sequencingskin disordersocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstem cellstranscription factortranscriptome sequencingtranscriptomic sequencingtranslation
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PROJECT SUMMARY/ABSTRACT
Although the epidermis is composed of morphologically distinct layers, single-cell RNA-seq experiments indicate
that epidermal differentiation does not progress in discrete steps at a transcript level but is instead continuous
and gradual. Consistent with this notion, we identified a large population of basal-to-spinous…
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