grant
Transcranial Magnetic Stimulation for MCI: A Phase II Dose-Response Study
Organization MEDICAL UNIVERSITY OF SOUTH CAROLINALocation CHARLESTON, UNITED STATESPosted 15 May 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AD related dementiaADRDAccelerationAddressAffectAffectiveAffective SymptomsAfter CareAfter-TreatmentAftercareAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmentiaApoplexyAttentionBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBiometricsBiometryBiostatisticsBrain Vascular AccidentBrain Vascular DisordersCNS plasticityCerebral StrokeCerebrovascular ApoplexyCerebrovascular DiseaseCerebrovascular DisordersCerebrovascular StrokeClinicClinicalClinical TrialsClinical assessmentsCognitionCognition DisordersCognitiveCognitive ManifestationsCognitive SymptomsCognitive deficitsCommunitiesConditioning TherapyDSM-5DSM-VDSM5DataDementiaDiagnosisDiagnosticDiagnostic SpecificityDiagnostic and Statistical Manual of Mental Disorders, 5th editionDiagnostic and Statistical Manual of Mental Disorders-VDisease remissionDorsalDoseDouble-Blind MethodDouble-Blind StudyDouble-BlindedDouble-Masked MethodDouble-Masked StudyDysfunctionElderly depressionEnsureFDA approvedFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsHealth Care CostsHealth CostsHeterogeneityIncidenceInterventionIntracranial Vascular DiseasesIntracranial Vascular DisordersLeftLiquid substanceMental DepressionMethodsNational Institutes of HealthNeurobehavioral ManifestationsNeurobehavioral Signs and SymptomsNeurocognitiveNeuronal PlasticityNeuropsychologiesNeuropsychologyParticipantPatientsPhasePhysiologic pulsePhysiopathologyPrefrontal CortexPsychometricsPulseRandomizedRandomized, Controlled TrialsRegulationRemissionSafetySchemeSecondary PreventionSiteStrokeSymptomsSyndromeTechniquesTestingTherapeuticTranscranial magnetic stimulationTreatment PeriodUnited States National Institutes of HealthVariantVariationVascular Cognitive ImpairmentVisualWorkaffective neuroscienceamnestic mild cognitive impairmentbehavior interventionbehavioral interventionbrain MR imagingbrain MRIbrain attackbrain circuitrybrain magnetic resonance imagingbrain vascular diseasebrain vascular dysfunctioncentral nervous system plasticitycerebral MR imagingcerebral MRIcerebral magnetic resonance imagingcerebral vascular accidentcerebral vascular diseasecerebral vascular dysfunctioncerebrovascular accidentcerebrovascular contribution to cognitive impairmentcerebrovascular contributions to cognitive dysfunctioncerebrovascular dysfunctionco-morbidco-morbid depressionco-morbid with depressionco-morbidityco-morbidity with depressioncognitive abilitycognitive controlcognitive defectscognitive diseasecognitive disordercognitive functioncognitive syndromecombinatorialcomorbid depressioncomorbid with depressioncomorbiditycomorbidity with depressiondementia riskdepressiondepression co-morbiditydepression comorbiditydesigndesigningefficacious therapyefficacious treatmentfMRIfluidgeriatric depressionimprovedinnovateinnovationinnovativeintracranial vascular dysfunctionlate life depressionliquidmild cognitive disordermild cognitive impairmentneural circuitneural circuitryneural plasticityneurobehavioral symptomneurocircuitryneuropathologicneuropathologicalneuropathologyneuroplasticneuroplasticityneuropsychiatricneuropsychiatric symptomneuropsychiatryneuropsychologicnon-invasive brain stimulationopen labelopen label studypathophysiologyphase 1 trialphase 2 trialphase I trialphase II trialpost treatmentpreventpreventingprimary outcomeprogression riskrandomisationrandomizationrandomized control trialrandomly assignedrecruitremediationrepetitive transcranial magnetic stimulationresponserisk factor for dementiarisk for dementiasecondary outcomestrokedstrokessynaptic circuitsynaptic circuitrytreatment daystreatment durationvascular and cognitive impairmentvascular cognition impairmentvascular cognitive declinevascular cognitive diseasevascular cognitive disordervascular cognitive dysfunctionvascular contributions to cognitive declinevascular contributions to cognitive impairmentvascular disease and impaired cognitionvascular dysfunction resulting in cognitive declinevascular related cognitive declinevascular related cognitive impairment
Description preview
PROJECT SUMMARY
Mild Cognitive Impairment (MCI) is a heterogenous syndrome of cognitive and neuropsychiatric symptoms. As
much as 40% of MCI patients have comorbid depression, which can significantly increase risk for dementia. We
propose that repetitive transcranial magnetic stimulation (rTMS), an FDA-approved treatment for depression,
may be a…
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