grant

Trans-Golgi Network Remodeling by Microbial Factors

Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Aug 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectAntibiotic AgentsAntibiotic DrugsAntibioticsAutoimmune DiseasesBacteriaCancersCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessDissectionEukaryotaEukaryoteEventFoundationsFutureGTP PhosphohydrolasesGTPasesGenesGoalsGramicidinGuanosine Triphosphate PhosphohydrolasesGuanosinetriphosphatasesHealthHumanInflammasomeInflammatoryIntracellular Communication and SignalingKnowledgeLigandsMaintenanceMalignant NeoplasmsMalignant TumorMedial GolgiMetabolic DiseasesMetabolic DisorderMetabolic GlycosylationMicrobeMiscellaneous AntibioticModern ManModificationMolecularMorphologyNatureNerve DegenerationNeuron DegenerationNigericinOrganellesOrganismPathway interactionsPeptidesPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProtein BiosynthesisProtein FamilyProtein ModificationProteinsRibosomal Peptide BiosynthesisRibosomal Protein BiosynthesisRibosomal Protein SynthesisRoleSignal TransductionSignal Transduction SystemsSignalingSortingStimulusStructureSubcellular ProcessTherapeuticThesaurismosisToxinVesicleVirusYeastsautoimmune conditionautoimmune disorderautoimmunity diseasebiological signal transductioncytokinegene manipulationgenetic manipulationgenetically manipulategenetically perturbglycosylationgolginguanosinetriphosphatasehuman diseaseinnovateinnovationinnovativeinsightliving systemmalignancymetabolism disordermicrobialneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnovelpathwayprotein synthesisrational designscreeningscreeningssmall moleculesocial roletooltrans-Golgi Network
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PROJECT SUMMARY
Eukaryotic trans-Golgi network (TGN) has been extensively studied for its role as the major sorting

compartment and the center for terminal processing and modifications of newly synthesized proteins. While the

TGN is known for its dynamic nature associated with the constant flux of traffic, whether its structures can be

altered in…

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Trans-Golgi Network Remodeling by Microbial Factors — UNIVERSITY OF CHICAGO | UNITED STATES | Aug 2023 | Dev Procure