grant
Tracking the dynamic trajectory of behavioral, physiological, and neurobiological stress responses in female adolescents at high and low familial risk for depression.
NIHUS FederalResearch GrantFY202512-20 years old15 year old15 years of age21+ years oldActive Follow-upAcuteAdolescenceAdolescentAdolescent YouthAdultAdult HumanAeroseb-HCAffectiveAutonomic nervous systemBehavioralBiological MarkersBrainBrain Nervous SystemCardiac ChronotropismCell PhoneCellular PhoneCellular TelephoneCetacortCharacteristicsCognitiveCort-DomeCortefCortenemaCortisolCortisprayCortrilDataDermacortDevelopmentDysfunctionEarly InterventionEarly identificationEldecortElectrodermal ResponseEmotional DepressionEncapsulatedEncephalonEnvironmentExhibitsFemaleFemale AdolescentsFunctional disorderFutureGalvanic Skin ResponseHeart RateHistoryHormonalHydrocortisoneHydrocortoneHytoneImageKnowledgeLaboratoriesLinkMajor Depressive DisorderMale AdolescentsMental DepressionMobile PhonesModelingNatureNeurobiologyNutracortOnset of illnessOutputParentsPatternPhysiologicPhysiologic PsychologyPhysiologicalPhysiological PsychologyPhysiopathologyPredispositionProcessProctocortPropertyPsychogalvanic ReflexPsychophysiologicalPsychophysiologyPsychosocial StressPublishingRecording of previous eventsRecurrenceRecurrentRelative RisksRestRiskRisk FactorsRisk MarkerRoleSamplingSkin Electric ConductanceSleepSleep disturbancesStressSusceptibilityTechnologyTestingTimeWorkYouthYouth 10-21aberrant sleepactive followupadolescence (12-20)adolescent boyadolescent girladulthoodage 15 yearsbehavior responsebehavioral responsebio-markersbiologic markerbiological adaptation to stressbiomarkerclinical depressioncomparing females and malescomparing women and mendepressiondepression symptomdepressivedepressive symptomsdevelopmentaldigital phenotypingdisease onsetdisease riskdisorder onsetdisorder riskdisrupted sleepdisturbed sleepearly adolescencefall asleepfemales compared to malesfemales compared with malesfemales versus malesfemales vs. malesfifteen year oldfifteen years of agefollow upfollow-upfollowed upfollowupheart rate variabilityhigh riskhigh-risk adolescentshistoriesiPhoneimagingimpaired sleepindexinginsightirregular sleepjuvenilejuvenile humanmachine learning based modelmachine learning modelmajor depressionmajor depression disordermalenegative affectnegative affectivityneuralneural mechanismneurobiologicalneuromechanismnoveloffspringparentpathophysiologyperceived stressperception of stressphenotypic biomarkerphenotypic markerphysiopsychologypoor sleepprospectivepsycho-physiologicalpsychosocial stressespsychosocial stressorsquality of sleepreaction; crisisresponserisk predictorrisk predictorsruminateruminationruminativeself-reported stressskin conductancesleep amountsleep disruptionsleep durationsleep dysregulationsleep episodesleep intervalsleep lengthsleep onsetsleep periodsleep qualitysleep quantitysleep timesleep/wake disruptionsleep/wake disturbancesmart phonesmart watchsmartphonesmartwatchsocial rolestress perceptionstress reactivitystress responsestress; reactiontime asleeptime during sleeptime in sleeptime spent asleeptime spent sleepingvulnerable adolescentwearablewearable devicewearable electronicswearable systemwearable technologywearable toolwearableswomen compared to menwomen compared with menwomen versus menwomen vs. menyouth age♀♂
Description preview
Project Summary/Abstract. Stress and a parental history of Major Depressive Disorder (MDD) are among the
most potent risk factors for future MDD development. Evidence suggests that the offspring of parents with
MDD are especially vulnerable to the development of maladaptive responses to stress. Early adolescence is a
critical window for studying…
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