grant
Tracing developmental signaling histories with imaging-based molecular recording
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Apr 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AddressAssayBioassayBiologicalBiological AssayBody TissuesBone-Derived Transforming Growth FactorCRISPRCRISPR/Cas systemCell BodyCell Communication and SignalingCell SignalingCellsClustered Regularly Interspaced Short Palindromic RepeatsCollaborationsComputer AnalysisCuesDNA mutationDataDecision MakingDevelopmentDevelopmental ProcessDiseaseDisorderEmbryoEmbryonicEngineeringExpression SignatureGene CombinationsGene Expression ProfileGenerationsGenetic ChangeGenetic defectGenetic mutationGenomeGoalsHeritabilityHistoryImageIndividualInstructionIntracellular Communication and SignalingKnowledgeLinkMediatingMemoryMilk Growth FactorModelingMolecularMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsMutationNatural regenerationNodalOpticsOrganogenesisPathway interactionsPhenotypePlatelet Transforming Growth FactorProgenitor CellsPublicationsRecording of previous eventsRegenerationResearchRoleScientific PublicationShapesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSystemTGF BTGF-betaTGF-βTGFbetaTGFβTechnologyTestingTimeTissue EngineeringTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family Genebase editorbioengineered tissuebiologicbiological signal transductioncellular developmentcomputational analysescomputational analysiscomputer analysesdevelopmentalengineered tissueepigenomicsfluorescence imagingfluorescent imaginggene expression patterngene expression signaturegenome mutationhistoriesimagingin vivointerdisciplinary approachinterestmESCmultidisciplinary approachmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellopticalpathwaypreservationprogramsquantitative imagingregenerateresponsesocial rolestem cellstranscriptional profiletranscriptional signature
Description preview
Project Summary
Signals that cells receive over time from a small set of pathways (e.g., BMP, Wnt, and TGFβ) shape their fate
and phenotype during development, regeneration, and disease. Despite their central importance, signaling
histories of individual cells are often inaccessible to direct observation, hindering quantitative analysis and…
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