grant
Towards the Design of a Programmable, Isoform-Selective Proteome Editing System
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 15 Jul 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AGRP proteinART proteinAgingAlgorithmsAmino Acid SequenceAmino AcidsArchitectureAreaBindingC-K-RASCRISPRCRISPR/Cas systemCancersCell BodyCellsClustered Regularly Interspaced Short Palindromic RepeatsCognitive DiscriminationComplementComplement ProteinsDeubiquitinationDiffusionDiscriminationDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseEngineeringEngineering / ArchitectureEnzyme GeneEnzymesGenerationsGoalsHD GeneHD proteinHuntingtinHuntingtin ProteinHuntington geneHuntington proteinHuntington's disease gene productIT15 geneInvestigationIsoformsK-RAS2AK-RAS2BK-RasK-Ras 2AK-Ras-2 OncogeneKRASKRAS2KRAS2 geneKi-RASLaboratoriesLanguageMalignant NeoplasmsMalignant TumorMasksMetabolic Protein DegradationModelingMolecular InteractionOncogene K-RasOncogenicPathogenicityPeptidesPhosphorylationPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPrimary Protein StructureProcessPropertyProtein IsoformsProtein ModificationProtein PhosphorylationProtein TurnoverProteinsProteomeRASK2Regulatory Protein DegradationResearchSwiss ProtSwissProtSystemTechnologyTrainingUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3ValidationVariantVariationWorkagouti-related proteinaminoacidcomplementationde-ubiquitinasede-ubiquitinating enzymedesigndesigningdiffuseddiffusesdiffusingdiffusionsgenerative AIgenerative artificial intelligencegenome editinggenomic editinginteresting transcript 15malignancymutantneoplasm/cancerprotein degradationprotein sequencetoolubiquitin isopeptidaseubiquitin-protein ligaseubiquitin-specific isopeptidasev-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homologvalidations
Description preview
Abstract
The proposed work in this MIRA application focuses on my long-term goal to create programmable toolkits for
proteome editing. Inspired by research into developing broad-targeting CRISPR enzymes for programmable
genome editing, my laboratory designs analogous peptide-guided enzymes for post-translationally modifying
target proteins from…
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