grant
Towards MRI-based detection and categorization of invasive high grade glioma subtypes
Organization ARIZONA STATE UNIVERSITY-TEMPE CAMPUSLocation SCOTTSDALE, UNITED STATESPosted 13 Dec 2024Deadline 30 Nov 2029
NIHUS FederalResearch GrantFY2026AstrocytesAstrocytusAstrogliaBBB disruptionBehaviorBiologicalBiopsyBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCancersCategoriesCell BodyCell Growth in NumberCell MultiplicationCell ProliferationCellsCellular ProliferationClinicalContrast-Enhancing LesionD-GlucoseDWI (diffusion weighted imaging)DWI-MRIDetectionDeuteriumDevelopmentDextroseDiagnosisDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingEncephalonEnhancing LesionExhibitsFailureGadolinium-Enhancing LesionGd-Enhancing LesionGeneral RadiologyGenerationsGliaGlial Cell TumorsGlial CellsGlial NeoplasmGlial TumorGliomaGlnGlucoseGlutamatesGlutamineGlycolysisGoalsH2 isotopeHumanImageImmune infiltratesImmunofluorescenceImmunofluorescence ImmunologicIncidenceInfiltrationIntermediary MetabolismInvadedKolliker's reticulumL-GlutamateL-GlutamineMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignant NeoplasmsMalignant TumorMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic ProcessesMetabolismMethodsMitochondriaModelingModern ManNMR ImagingNMR TomographyNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeuritesNeurocyteNeurogliaNeuroglial CellsNeuroglial NeoplasmNeuroglial TumorNeuronsNeurontinNeurotransmittersNon-neuronal cellNonneuronal cellNuclear Magnetic Resonance ImagingOperative ProceduresOperative Surgical ProceduresPatientsPhenotypePredispositionProcessQ LevoglutamideQ. LevoglutamideRadiologyRadiology SpecialtyRecurrenceRecurrentStructureSurgicalSurgical InterventionsSurgical ProcedureSusceptibilitySynapsesSynapticT-StageTherapeuticTissue SampleTubeTumor CellTumor stageWorkZeugmatographyastrocytic gliabiologicblood-brain barrier disruptionbloodbrain barrier disruptionbrain parenchymacancer progressionchemo-/radio-therapychemo-radiotherapychemoradiationchemoradiation therapychemoradiation treatmentchemoradiotherapycontrast enhanceddMRIdensitydevelopmentaldifferential expressiondifferentially expresseddiffusion tensor imaginggabapentinglial-derived tumorglutamatergicimagingimmune cell infiltratein vivoinhibitormalignancymitochondrialneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnerve cementneuroglia neoplasmneuroglia tumorneuronalprogenitorradio-chemo-therapyradio-chemotherapyradiochemotherapyscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingstandard of caresurgerysynapsetooltranscriptional differencestumortumor progressiontumors in the brainuptake
Description preview
PROJECT SUMMARY
The goal of this work is to detect and differentiate with MRI the invasive NEU and GPM high-grade glioma
subtypes based on their divergent microstructure, glycolytic metabolism, and glutaminergic synapse profiles.
High grade glioma (HGG) brain tumors rank among the most lethal of all human cancers, with a median survival
of ~17…
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