grant
Towards a biophysical model of human cortical neurophysiological signatures that incorporates cellular and cell type biophysics, transcriptomics, and morphology
Organization CEDARS-SINAI MEDICAL CENTERLocation LOS ANGELES, UNITED STATESPosted 15 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025AffectArchitectureBiologicalBiological MarkersBiophysical ProcessBiophysicsBrainBrain Nervous SystemCatalogsCationsCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCell modelCellsCellular FunctionCellular PhysiologyCellular ProcessCellular modelCensusesCharacteristicsCollectionCommunitiesComputational toolkitComputer ModelsComputerized ModelsDataData SetDetectionElectrophysiologyElectrophysiology (science)EncephalonEngineering / ArchitectureExhibitsExpression SignatureFrequenciesGene Expression ProfileGene TranscriptionGenerationsGenetic TranscriptionGoalsHumanIndividualIntracellular Communication and SignalingIon ChannelIonic ChannelsLinkMeasurableMeasurementMeasuresMembrane ChannelsModalityModelingModern ManMorphologyNeocortexNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurophysiology / ElectrophysiologyPatch TestsPatternPerformancePhysiologyProceduresPropertyPyramidal neuronRNA ExpressionResearch ResourcesResolutionResourcesRoleSignal TransductionSignal Transduction SystemsSignalingSourceStress TestsSubcellular ProcessSynapsesSynapticTestingTranscriptionTranslatingValidationbio-markersbiologicbiologic markerbiological signal transductionbiomarkerbiophysical foundationbiophysical mechanismbiophysical modelbiophysical principlesbiophysical sciencescatalogcell cortexcell typecomputational modelingcomputational modelscomputational toolboxcomputational toolscomputational toolsetcomputer based modelscomputer based predictioncomputerized modelingcomputerized toolsdensityelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsextracellularfeasibility testinggene expression patterngene expression signaturehippocampal pyramidal neuronhomotypical cortexhuman modelin vivoinsightisocortexlarge scale datalarge scale data setslarge scale datasetsmodel buildingmodel of humanmodel-based simulationmodels and simulationmulti-modal datamulti-modal datasetsmulti-modalitymultimodal datamultimodal datasetsmultimodalityneocorticalneopalliumneuralneural circuitneural circuitryneurocircuitryneuronalneurophysiologicalneurophysiologynovelpatch clamppotential biological markerpotential biomarkerpredictive modelingresolutionsresponsesimulationsocial rolespatial and temporalspatial temporalspatiotemporalstatistical learningsynapsesynaptic circuitsynaptic circuitrytooltranscriptional profiletranscriptional signaturetranscriptomicstranslational applicationsvalidations
Description preview
Project Summary
The past decade has seen an unprecedented accumulation of data at the single-cell level giving rise to unique,
multimodal sets of gene expression patterns, morphologies, and electrophysiology characteristics. This high-
resolution census of neuronal types in the brain constitutes an essential step towards a mechanistic…
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