grant
Toward a neuroscientific understanding of the interaction between Down syndrome and Alzheimer's disease pathology
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD pathologyActive Follow-upAdultAdult HumanAgeAge related pathologiesAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's diagnosisAlzheimer's disease biological markerAlzheimer's disease diagnosisAlzheimer's disease pathologyAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmmon HornAmyloidAmyloid SubstanceBiological MarkersBlood PlasmaBrainBrain Nervous SystemBrain PathologyBrain regionCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesClinicalCognitiveComputing MethodologiesCornu AmmonisCorpus StriatumCorpus striatum structureDWI (diffusion weighted imaging)DWI-MRIDataDementiaDevelopmentDiagnosisDiffusionDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDimensionsDisease ProgressionDown SyndromeEncephalonEnrollmentFunctional MRIFunctional Magnetic Resonance ImagingGeneral PopulationGeneral PublicGoalsHippocampusIndividualIndividuals with down syndromeInterventionInvestigatorsK-AwardsK-Series Research Career ProgramsKnowledgeLangdon Down syndromeLightLiquid substanceMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMongolismNMR ImagingNMR TomographyNerve DegenerationNeuron DegenerationNeuropsychologiesNeuropsychologyNeurosciencesNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPETSCANPETTPathologicPatientsPatternPhenotypePhotoradiationPlasmaPlasma SerumPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPreventative treatmentPreventive treatmentPrimary Senile Degenerative DementiaPropertyRad.-PETResearch Career ProgramResearch PersonnelResearchersRestReticuloendothelial System, Serum, PlasmaSpectroscopySpectrum AnalysesSpectrum AnalysisStriate BodyStriatumStructureSymptomsTestingTrainingTranslational ResearchTranslational ScienceTrisomy 21ValidationWorkZeugmatographyactive followupadulthoodage associated pathologiesage dependent pathologiesage induced pathologiesagesaging associated pathologiesaging biological markeraging biomarkeraging dependent pathologiesaging induced pathologiesaging markeraging pathologiesaging related pathologiesbio-markersbiologic markerbiomarkerbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertiesbrain tissuecareerchromosome 21 trisomychromosome 21 trisomy syndromeclinical translationclinically translatablecohortcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methodcongenital acromicria syndromeconnectomeconnectome based predictive modelingdMRIdesigndesigningdevelop therapydevelopmentaldiffuseddiffusesdiffusingdiffusion tensor imagingdiffusionsdown syndrome individualsdown syndrome patientsenrollexecutive controlexecutive functionfMRIfluidfollow upfollow-upfollowed upfollowuphippocampalin vivoinnovateinnovationinnovativeinsightintervention developmentlife spanlife-time risklifespanlifetime riskliquidmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmodel generalizabilitymorbus Downmulti-modal neuro-imagingmulti-modalitymultimodal neuroimagingmultimodalityneural degenerationneural imagingneuro-imagingneurodegenerationneurodegenerativeneurofilamentneuroimagingneurological degenerationneurological imagingneuronal degenerationneuropathologicneuropathologicalneuropathologyneuropsychiatricneuropsychiatryneuropsychologicnovelpatients with down syndromepeople with down syndromepositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerprimary degenerative dementiapseudohypertrophic progressive muscular dystrophysenile dementia of the Alzheimer typeskillssocial cognitionstriataltautau Proteinstau factortherapy developmenttranslation researchtranslational investigationtreatment developmenttrisomy 21 syndromevalidationsvectorτ Proteins
Description preview
This application will combine the neuroimaging expertise of the investigator with new knowledge of biomarkers
for aging pathology, advanced computational methods and Down syndrome clinical translational research. The
goal is to produce a unique skill set which will be used to advance the candidate’s career as an independent
lifespan developmental…
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