grant
Top-down modulation of the dorsal cochlear nucleus
Organization ARIZONA STATE UNIVERSITY-TEMPE CAMPUSLocation SCOTTSDALE, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026Acoustic NerveAcoustic Perceptual DisorderAcousticsAcuteAffectAlogiaAnatomic SitesAnatomic structuresAnatomyAnepiaAnimalsAphasiaAuditoryAuditory Comprehension DisorderAuditory PerceptionAuditory Perceptual DiseasesAuditory Perceptual DisordersAuditory Processing DisorderAuditory systemAxonAxon TerminalsBackBrainBrain Nervous SystemBrush CellCNS Nervous SystemCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCentral Nervous SystemCochleaCochlear OrganCochlear nucleusComplexConnector NeuronCranial Nerve EightCranial Nerve VIIICuesDataDetectionDorsumDyslexiaEighth Cranial NerveElectrophysiologyElectrophysiology (science)EncephalonEnvironmentFeedbackFiberFrequenciesFusiform CellGeneticGlutamatesHearingHearing LossHypoacusesHypoacusisImpairmentIn VitroInferior ColliculusIntercalary NeuronIntercalated NeuronsInterneuronsInternuncial CellInternuncial NeuronIntracellular Communication and SignalingKnowledgeL-GlutamateLabelLocationLogagnosiaLogamnesiaLogastheniaMiceMice MammalsModernizationMorphologyMovementMurineMusNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurosciencesNoiseNucleusPathway interactionsPerceptionPersonsPlayPopulationPosterior Quadrigeminal BodyPresynaptic Nerve EndingsPresynaptic TerminalsProcessPropertyPsychoacoustical DisordersResistanceRoleSensoryShapesSignal TransductionSignal Transduction SystemsSignalingSliceSynapsesSynapticSynaptic BoutonsSynaptic TerminalsTestingTransgenic MiceVIIIth Cranial NerveVestibulocochlear NerveWord BlindnessWorkauditory nerveauditory pathwayauditory processingawakebiological signal transductionbody movementcell typecentral processing disorderdorsal cochlear nucleusdysfunctional hearingelectrophysiologicalglutamatergicgranule cellhearing challengedhearing defecthearing deficienthearing deficithearing difficultyhearing dysfunctionhearing impairmenthearing perceptionimprovedin vivoinsightneuralneural circuitneural circuitryneural mechanismneurocircuitryneuromechanismneuronalneurophysiologicalneurophysiologyoptogeneticspatch clamppathwayphenomenological modelsphenomenologypreservationresistantresponsesensory systemsocial rolesoundsound perceptionsynapsesynaptic circuitsynaptic circuitry
Description preview
PROJECT SUMMARY
An animal’s survival depends on their accurate perception of biologically relevant sounds in a complex
hearing environment that is awash with background noise. Top-down contextual information modulates the
processing of bottom-up sensory signals at multiple levels of the auditory pathway to improve hearing
accuracy, but the neural…
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