grant
Toll-like receptor control of endocytic antigen cross-presentation
Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-KinaseAIDS VirusARAMAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAdjuvantAg Recognition Activation MotifAlum AdjuvantAntibodiesAntigen PresentationAntigen-Presenting CellsAntigensB pertussis infectionB. pertussis infectionBacteriaBindingBody TissuesBordetella pertussis infectionBreakbone Fever VirusCD14CD14 geneCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCell BodyCell Communication and SignalingCell Mediated ImmunologyCell SignalingCell membraneCell-Mediated ImmunityCellsCellular ImmunityCellular biologyClass I GenesClinicalCross PresentationCytoplasmic DomainCytoplasmic MembraneCytoplasmic TailDENVDendritic CellsDengue VirusDengue fever virusDevelopmentDiameterEBOVEbola virusEbola-like VirusesEndocytosisEndosomesGrippeHBV diseaseHIVHPV VaccineHepBHepatitis AHepatitis BHistocompatibility ComplexHistocompatibility ComplicesHuman Immunodeficiency VirusesHuman Papilloma Virus VaccineHuman papillomavirus VaccineITAMImmune memoryImmune systemImmunityImmunologic MemoryImmunological MemoryImmunoreceptor Tyr-Based Activation MotifImmunoreceptor Tyrosine-Based Activation MotifInfectionInfection ControlInflammatory ResponseInfluenzaInfluenza AInfluenza A virusInfluenza Viruses Type AInfluenzavirus AInositide PhospholipidsInositol PhosphoglyceridesInositol PhospholipidsIntracellular Communication and SignalingLAV-HTLV-IIILicensingLigandsLiposomalLiposomesLymphadenopathy-Associated VirusM tuberculosis infectionM. tb infectionM. tuberculosis infectionM.tb infectionM.tuberculosis infectionMHC Class IMHC Class I GenesMTB infectionMajor Histocompatibility ComplexMajor Histocompatibility ComplicesMalariaMediatingMembraneMemoryMeningococcal vaccineMiceMice MammalsMicrobeMolecular InteractionMurineMusMutateMycobacterium tuberculosis (MTB) infectionMycobacterium tuberculosis infectionNatureNucleoproteinsOrthoebolavirusOrthomyxovirus Type API-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePIP2PaludismParticulatePathway interactionsPeptidesPertussisPhagocytesPhagocytic CellPhagocytosisPhosphatidyl InositolPhosphatidylinositol 3-KinasePhosphatidylinositol 4,5-BiphosphatePhosphatidylinositol 4,5-DiphosphatePhosphatidylinositol-3-OH KinasePhosphatidylinositol-4,5-BisphosphatePhosphatidylinositolsPhosphoinositide 3-HydroxykinasePhosphoinositidesPlasma MembranePlasmodium InfectionsPlayPneumococcal vaccineProcessProteinsPtIns 4,5-P2PtdInsPtdIns 3-KinasePtdInsP2PublishingQS 21QS-21 AdjuvantQS21Receptor CellReceptor ProteinReceptor SignalingReceptosomesRecombinant ProteinsRecyclingRegulationRoleRouteSaponinsSignal TransductionSignal Transduction SystemsSignalingSiteSourceStimulon QS-21 AdjuvantStreptococcus pneumoniae vaccineSubunit VaccinesT cell responseT memory cellT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTB infectionTIL4TLR proteinTLR2TLR2 geneTLR2 receptorTechnologyTissuesToll-Like Receptor 2Toll-Like Receptor Family GeneToll-like receptorsToll/Interleukin 1 Receptor-Like 4Toll/Interleukin 1 Receptor-Like 4 GeneToll/Interleukin 1 Receptor-Like Protein 4TuberculosisType A InfluenzaType I Phosphatidylinositol KinaseType III Phosphoinositide 3-KinaseVaccinatedVaccinationVaccine AntigenVaccinesVeiled CellsVesicleViralViral Hepatitis BVirusVirus-HIVVirus-like particleWhooping Coughaccessory cellalumaluminum sulfateamebocyteanamnestic reactionbiological signal transductioncell biologyclinical relevanceclinically relevantcytotoxic CD8 T cellscytotoxic CD8 T lymphocytedesigndesigningdevelopmentaldisseminated TBdisseminated tuberculosisemerging pathogenflu virus pandemichep Bhepatitis B virus diseaseimmunogenin vivoinfected with B pertussisinfected with B. pertussisinfected with Burkholderia pertussisinfection due to Mycobacterium tuberculosisinfluenza virus pandemicmembrane structurememory T lymphocytemicrobialmicrobial antigenmicroorganism antigennano particlenano-sized particlenanoparticlenanosized particlenew pathogennovelnovel pathogenpandemic concernpandemic flupandemic influenzapandemic potentialpandemic riskpandemic strain of influenzapandemic threatparticlepathogenpathwayplasmalemmapreventpreventingprototypereceptorreceptor-mediated signalingrecruitsecondary immune responsesocial rolesuccesstraffickingtuberculosis infectiontuberculous spondyloarthropathytumorunpublished worksvaccine formulationvirus-like nanoparticlesviruslike particle
Description preview
PROPOSAL SUMMARY
There are critical vaccine barriers to eliciting cytotoxic CD8 T cells against intracellular pathogens. Current
vaccine technologies have yielded limited success for protection against infections with intracellular pathogens
like tuberculosis, malaria, and HIV where CD8 T cells prevent and control infection. Licensed vaccines…
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