grant
TNFRSF13B polymorphisms and immunity to transplantation
Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 15 Aug 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY20255' Untranslated Regions5'UTRAb responseAcquired AgammaglobulinemiaAddressAffinityAllelesAllelomorphsAlloantibodiesAlloantigenAntibodiesAntibody AffinityAntibody FormationAntibody ProductionAntibody ResponseAntigensAvidityB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBasal Transcription FactorBasal transcription factor genesBindingBlood SerumC3bCSIFCSIF-10Cardiac TransplantationCell BodyCell CoatCell Communication and SignalingCell SignalingCellsClonal ExpansionClone CellsCommon Variable ImmunodeficiencyComplementComplement 3bComplement C3bComplement Factor HComplement Factor PComplement ProteinsCytokine Synthesis Inhibitory FactorDNADNA mutationDefectDeoxyribonucleic AcidDevelopmentEngineeringEvolutionExhibitsFactor HFixationGene ExpressionGene SplicingGeneral Transcription Factor GeneGeneral Transcription FactorsGenerationsGenesGenetic ChangeGenetic PolymorphismGenetic defectGenetic mutationGenomicsGenotypeGerm LinesGlycocalyxGrafting ProcedureHeart GraftingHeart TransplantationHumanIL-10IL10IL10AImmune GlobulinsImmunityImmunoglobulinsInterleukin 10 PrecursorInterleukin-10Intracellular Communication and SignalingInvestigatorsIsoantibodiesKO miceKidney GraftingKidney TransplantationKidney TransplantsKineticsKnock-out MiceKnockout MiceMediatingMiceMice MammalsMichiganModern ManMolecular InteractionMurineMusMutateMutationNull MouseOrgan TransplantationOrgan TransplantsOutcomePathogenicityPathologyPhenotypePhysiologicPhysiologicalPopulationProductionProperdinPropertyPublicationsRenal GraftingRenal TransplantationRenal TransplantsReportingResearchResearch PersonnelResearchersSamplingScientific PublicationSerumSignal TransductionSignal Transduction SystemsSignalingSpliced GenesTestingTranscriptTranscription Factor Proto-OncogeneTranscription factor genesTransplant RecipientsTransplantationVariantVariationalloimmunityantibody biosynthesisantibody rejectionantibody-mediated rejectionantigen antibody affinitybiobankbiological signal transductionbiorepositorycardiac allograftcardiac graftcommon variable immune deficiencycomplementationdevelopmentaldonor antibodiesdonor-specific antibodyfactor Pgenome mutationgraft functionheart allograftheart transplanthypogammaglobulinemiaimmunogenimmunoglobulin biosynthesisinjury responseisoimmunitykidney txmRNA Leader Sequencesmouse modelmurine modelmutantnatural antibodiesnon-synonymous mutationnonsynonymous mutationnonsynonymous single nucleotide polymorphismnonsynonymous single nucleotide variantnonsynonymous single-nucleotide substitutionnonsynonymous variantorgan allograftorgan graftorgan xenograftplasma cell differentiationpolymorphismreceptor functionrecruitresponseresponse to injurysample fixationtranscription factortransplanttransplant centerstransplant modeltransplant patient
Description preview
Abstract:
The proposed research investigates how genomic polymorphism of the TNFRSF13B locus
predicts and potentially governs the character and outcome transplantation immunity in humans.
The investigators recently found (de Mattos Barbosa et al., 2021) non-synonymous mutations of
TNFRSF13B occur 5-fold more often in kidney transplant recipients…
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