grant
TMEM16A in human airway disease
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAirAirway DiseaseAirway healthAnionsAssayAsthmaBicarbonatesBioassayBiologic ModelsBiological AssayBiological ModelsBiologyBody TissuesBronchial AsthmaCF airwayCFTRCFTR ProteinCOPDCalciumCell BodyCell LineCell NucleusCell modelCellLineCellsCellular modelChemosensitizationChemosensitization/PotentiationChloride ChannelsChloride Ion ChannelsChloridesChronic Obstruction Pulmonary DiseaseChronic Obstructive Lung DiseaseChronic Obstructive Pulmonary DiseaseCo-cultureCocultivationCocultureCoculture TechniquesCompensationComplementComplement ProteinsComplexCryo-electron MicroscopyCryoelectron MicroscopyCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDataDevelopmentDiseaseDisorderDysfunctionElectron CryomicroscopyEpitheliumExhibitsFISH TechnicFISH TechniqueFISH analysisFISH assayFamily memberFluorescence In Situ HybridizationFluorescent in Situ HybridizationFunctional disorderHCO3HumanHydrationHydration statusHydrogen CarbonatesImageImpairmentIn VitroIntegral Membrane ProteinIntrinsic Membrane ProteinInvestigationIon ChannelIonic ChannelsIsoformsKnowledgeLimesLiquid substanceLungLung Respiratory SystemMacromolecular StructureMediatingMembrane ChannelsModel SystemModelingModern ManMolecularMolecular StructureMucociliary ClearanceMucociliary TransportMucous body substanceMucoviscidosisMucusNHLBINational Heart, Lung, and Blood InstituteNucleusObstructionPatientsPatternPhysiopathologyPlayPopulationPotentiationPropertyProtein IsoformsProtein SecretionProtein SubunitsProteinsRNA SeqRNA SplicingRNA sequencingRNAseqRegulationResearchResearch SpecimenRoleSeriesSingle-Nucleus SequencingSliceSpecimenSplicingStrains Cell LinesStructureSystemTestingTherapeuticTissue ModelTissuesTransmembrane ProteinTransmembrane Protein GeneWorkanti-microbialantimicrobialbiophysical characteristicsbiophysical characterizationbiophysical measurementbiophysical parametersbiophysical propertieschronic obstructive pulmonary disordercomplementationcryo-EMcryoEMcryogenic electron microscopycultured cell linecystic fibrosis airwaycystic fibrosis transmembrane regulatordevelop therapydevelopmentalexperimentexperimental researchexperimental studyexperimentsfluidhuman diseasehuman modelimaginginsightinterestintervention developmentliquidloss of function mutationmodel of humanmucousmultidisciplinarynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetparticlepatch clamppathophysiologyprotein functionrespiratory healthsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicstargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettherapy developmentthree dimensionaltooltranscriptome sequencingtranscriptomic sequencingtranscriptomicstreatment development
Description preview
ABSTRACT
Chloride channels contribute to airway health and disease by modulating airway secretion and mucociliary
function. We discovered that the channel regulator CLCA1 is a potent and specific potentiator of the TMEM16A
calcium-activated chloride channel, but there remains a major gap in understanding how this pair influences
airway biology. In…
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