grant
Tissue specific immunity to fungal infections
Organization HACKENSACK UNIVERSITY MEDICAL CENTERLocation HACKENSACK, UNITED STATESPosted 22 Nov 2024Deadline 31 Oct 2029
NIHUS FederalResearch GrantFY2026AcetylationAnimal ModelAnimal Models and Related StudiesAntigen-Antibody ComplexAttenuatedBiologyBlood leukocyteBody TissuesBuccal MucosaC albicansC. albicansC.albicansCandidaCandida albicansCandidiasisCandidosisCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCessation of lifeComplexDataData SetDeathDisseminated candidiasisDisseminated candidosisDrug TargetingEnvironmentEpithelial CellsExpression ProfilingFaceFungal Drug ResistanceFungus DiseasesFungus drug resistantGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGeneticGoalsHistone AcetylationHistone H3Host DefenseImmuneImmune ComplexImmune SurveillanceImmune systemImmunesImmunityImmunocompromisedImmunocompromised HostImmunocompromised PatientImmunologic SurveillanceImmunosuppressed HostImmunosurveillanceIn VitroIndividualInfectionKnowledgeL-LysineLeukocytesLeukocytes Reticuloendothelial SystemLysineMacrophageMarrow leukocyteMediatingMiceMice MammalsMissionModelingMolecularMoniliaMoniliasisMouth MucosaMucosaMucosal Immune SystemMucosal ImmunityMucosal TissueMucous MembraneMurineMusMycosesMyelogenousMyeloidMφNational Institutes of HealthOralOral MucosaOral mucous membrane structureOrganOropharyngealOropharyngeal CandidiasisOropharynxOropharynxsOutcomePathogenesisPathogenicityPathway interactionsPhagocytesPhagocytic CellPlayProtein AcetylationProteinsProteomicsPublic HealthRNA SeqRNA sequencingRNAseqRegulationResearchRoleSubcellular ProcessSurfaceSystemic candidaSystemic candida infectionsSystemic candidiasisSystemic infectionTestingTherapeutic FungicidesTissuesTransferaseTransferase GeneUnited States National Institutes of HealthVaginaValidationVirulenceWhite Blood CellsWhite Cellamebocyteanti-fungalanti-fungal agentsanti-fungal druganti-fungal drug resistanceanti-fungal drug resistantanti-fungal resistanceanti-fungal resistantattenuateattenuatescandidate identificationcell typechromatin remodelingcomparativefacesfacialfitnessfungal infectionfungal pathogenfungi pathogenfungus drug resistancefungus infectiongene regulatory networkhuman diseasehuman pathogenimmunosuppressed patientin vivoinfection mouthintra-vital imagingintravital imagingmicrobe pathogenmicrobial pathogenmodel of animalmouse modelmurine modelnon-histone proteinnonhistone proteinnoveloral cavity epitheliumoral epitheliaoral epitheliumoral infectionoral infectiousoral mucosaeoral mucosaloral pharyngealoropharyngeal thrushpathogenpathogenic funguspathogenic microbepathwaypressureresistance to anti-fungalresistant to anti-fungalresponsesocial roletranscriptome sequencingtranscriptomic sequencingvalidationswhite blood cellwhite blood corpuscleyeast infection
Description preview
Project summary/abstract
Candida albicans is a major opportunistic fungal pathogen of humans, which colonizes mucosal surfaces (oral, gut, vaginal
tract) in many individuals and can cause serious systemic (i.e., invasive candidiasis) and mucosal infections (e.g.
oropharyngeal candidiasis) in immunocompromised patients. Although it is well…
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