grant
Tissue-immunoengineering of TMJ neodisc implants
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 22 Aug 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AddressAffectAllogenicAllograftingAmericanAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAreaAssayB cell growth factorB-Cell Differentiation Factor-1B-Cell Growth Factor-1B-Cell Growth Factor-IB-Cell Proliferating FactorB-Cell Stimulating FactorB-Cell Stimulating Factor-1B-Cell Stimulation Factor-1B-Cell Stimulatory Factor-1BCDF-1BCGFBCGF-1BCSF 1BSF-1BSF1BinetrakinBioassayBiochemicalBiochemistryBiological AssayBiological ChemistryBiomechanicsBloodBlood Cell CountBlood Cell NumberBlood Reticuloendothelial SystemBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemCSIFCSIF-10CartilageCartilaginous TissueCell BodyCell-Extracellular MatrixCellsChondrocytesClinicalCo-cultureCocultivationCocultureCoculture TechniquesCollaborationsCommunicationCytokine Synthesis Inhibitory FactorDataDefectDiarthrosisDisease ProgressionECMEngineeringEnvironmentExposure toExtracellular MatrixGenerationsGrowth AgentsGrowth FactorGrowth SubstancesHistologicHistologicallyIL-10IL-13IL-4IL10IL10AIL13IL4 ProteinImmuneImmune responseImmunesImplantIn VitroIndividualInflammatoryInterleukin 10 PrecursorInterleukin-10Interleukin-13Interleukin-4Interleukin-4 PrecursorInterventionJaw JointLaboratoriesLeannessLymphocyte Stimulatory Factor 1MCGF-2MacrophageMandibular jointMast Cell Growth Factor-2MeasuresMechanical StimulationMechanicsMediatingMembrana Synovialis Capsulae ArticularisMembraneMiniature SwineMinipigsModelingMorbidityMorbidity - disease rateMφOutcomeParacrine CommunicationParacrine SignalingPathway interactionsPerforationPersonsPorosityPropertyProteins Growth FactorsProteomicsReactionRegimenResistanceRoleStimulusStretchingStructure of articular disc of temporomandibular jointSynovial MembraneSynovial jointSynoviumSystemT-Cell Growth Factor 2TMJTMJ DiscTemporomandibular Articular DiskTemporomandibular JointTemporomandibular Joint DiskTestingThinnessTissue EngineeringTissuesUnited StatesWorkbioengineered tissuebiomechanicalcell bankcell typecytokineengineered immune systemengineered tissuehealinghost responseimmune engineeringimmune system responseimmunoengineeringimmunoresponseimplantationimprovedin vivoinsightmechanicmechanicalmechanical cuemechanical propertiesmechanical signalmembrane structuremini pigmini-swineminiswinenew approachesnovelnovel approachesnovel strategiesnovel strategyparacrinepathwaypreventpreventingrepairrepairedresilienceresilientresistantresponsesafety assessmentscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesuccesstissue repair
Description preview
PROJECT SUMMARY
Temporomandibular joint (TMJ) disc perforations pose devastating morbidities for millions of Americans.
Interventions to slow or prevent progression of this disease do not exist. Toward addressing this as-of-yet
intractable problem, tissue-engineered neodisc constructs made with allogeneic costal chondrocytes have
shown promise in…
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