grant
Time resolved structural analyses of β-lactam/β-lactam inhibitor binding to AmpC
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY2026A baumanniA baumanniiA. baumanniA. baumanniiA.baumanniiAcinetobacter baumanniAcinetobacter baumanniiAcylationAffectAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibioticsAntimicrobial ResistanceBacteriaBacterial InfectionsBeta-Lactam resistantBindingBiochemicalBiochemical ReactionBiologicalBiologyCarbapenemsCatalysisCeftazidimeCephalosporinsCessation of lifeChemistryCommunity Health CareComplexCoupledCrystallographiesCrystallographyCyclicityDNA mutationDataData SetDeathEffectivenessEnzymatic ReactionEnzyme GeneEnzymesG24 proteinGenetic ChangeGenetic defectGenetic mutationGoalsGram-Negative BacteriaHealth Care SystemsHumanHydrolysisImipemideImipenemInfectionInfection ControlKineticsKnowledgeLactam AntibioticsMeasuresMethodsMiscellaneous AntibioticModern ManMolecular InteractionMonobactam AntibioticsMonobactamsMonocyclic beta-LactamsMultienzyme ComplexesMutationN-FormimidoylthienamycinP aeruginosaP. aeruginosaPenicillinsPeriodicityPredispositionPseudomonas aeruginosaPseudomonas pyocyaneaPublic HealthReactionResistanceResistance to antibioticsResistant to antibioticsResolutionRhythmicitySafetyStructureSubstrate SpecificitySulfone Anti-Infective AgentSulfonesSusceptibilityTimeanti-microbialanti-microbial resistantantibiotic drug resistanceantibiotic resistantantimicrobialb lactam resistanceb-lactam resistantbacteria infectionbacterial diseasebeta lactam antibioticbeta lactam hydrolasebeta-Lactam Resistancebeta-Lactamasebeta-Lactamhydrolasebeta-Lactamsbiologiccarbapenem resistancecarbapenem resistantclinical practicecommunity caredeacylationenzyme complexexperimentexperimental researchexperimental studyexperimentsgenome mutationimprovedindividual patientinhibitorinsightnovelpreservationresistance against beta lactamsresistance against carbapenemsresistance mechanismresistance to anti-microbialresistance to b lactamresistance to beta-lactamresistance to carbapenemresistance to β-Lactamresistantresistant mechanismresistant to antimicrobialresistant to b lactamresistant to beta-lactamresistant to carbapenemresistant to β-Lactamresolutionstemperature jumptreatment strategyβ lactam antibioticβ-Lactam Resistanceβ-Lactam resistantβ-Lactamaseβ-Lactams
Description preview
SUMMARY
Antibiotic resistance is a widespread phenomenon and represents a global threat that is associated with nearly
five million deaths a year globally. β-lactams are the most widely used class of antibiotics in treating human
infection because of their proven safety and effectiveness. β-lactam resistance refers to the ability of bacteria
to…
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