grant
Thyroid Hormone as a Key Regulator of Neurodevelopment during Early Life Iron Deficiency
Organization UNIVERSITY OF MINNESOTALocation MINNEAPOLIS, UNITED STATESPosted 9 Sept 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY20250-11 years old0-4 weeks old21+ years oldAD/HDADHDAcuteAddressAdultAdult HumanAffectAmmon HornAnemiaAttention deficit hyperactivity disorderAutoregulationBasal Transcription FactorBasal transcription factor genesBehaviorBiologicalBlood SerumBrainBrain Nervous SystemCell Communication and SignalingCell SignalingCellular NeurobiologyChildChild YouthChildren (0-21)Clinical ManagementCognition DisordersCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCommon Rat StrainsComplexCornu AmmonisCoupledDataDevelopmentDietary IronDisturbance in cognitionDysfunctionEducationEducational aspectsElectrophysiologyElectrophysiology (science)EncephalonFe deficiencyFe elementFetusFunctional disorderGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGenetic TranscriptionGestationGrowthHIF 1 alphaHIF-1alphaHIF1-AlphaHIF1AHIF1A geneHIF1αHealthHematologyHippocampusHomeostasisHumanImpaired cognitionImpairmentIntermediary MetabolismIntervention StrategiesIntracellular Communication and SignalingIronIron deficiency anemiaJobsKnowledgeLearningLeftLifeLong-Term EffectsMOP1MediatingMemoryMental DepressionMental HealthMental HygieneMental disordersMental health disordersMessenger RNAMetabolicMetabolic ProcessesMetabolic hormoneMetabolic stressMetabolismMiceMice MammalsMitochondriaModelingModern ManMotorMurineMusNeonatalNerve CellsNerve UnitNeural CellNeural DevelopmentNeurocyteNeurodevelopmental DeficitNeurodevelopmental ImpairmentNeuronsNeurophysiology / ElectrophysiologyNewborn InfantNewbornsNutrition DisordersNutritional DisordersOccupationsOutcomeOxidative StressPathway interactionsPhysiological HomeostasisPhysiopathologyPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPregnancyPregnant WomenProductionProfessional PositionsPsychiatric DiseasePsychiatric DisorderPsychological HealthPublic HealthPublishingRNA ExpressionRatRats MammalsRattusRecoveryRegulationRiskRisk FactorsRodent ModelSchizophreniaSchizophrenic DisordersSerumSignal TransductionSignal Transduction SystemsSignalingSocial DevelopmentSocietiesStressStructureTSH ReceptorsTestingTherapeutic InterventionThyroid DiseasesThyroid Function TestsThyroid Gland DiseaseThyroid Gland DisorderThyroid Gland Function TestsThyroid Gland HormoneThyroid Hormone ReceptorThyroid HormonesThyroid Stimulating Hormone ReceptorsThyrotropin ReceptorTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTranscriptional ControlTranscriptional RegulationTranslatingabnormal brain functionadulthoodbiologicbiological signal transductionbrain dysfunctionbrain impairmentbrain shapeclinical relevanceclinical translationclinically relevantclinically translatablecognitive defectscognitive developmentcognitive diseasecognitive disordercognitive dysfunctioncognitive losscognitive syndromecostdementia praecoxdepressiondevelop therapydevelopmentaldietary Fedysfunctional brainelectrophysiologicalexpectant motherexpectant womenexpecting motherexpecting womenfetalhippocampalhormone deficiencyhormone metabolismimprovedin vitro Modelin vivoindividuals who are pregnantintervention developmentintervention therapyiron deficiencykidslife spanlifespanmRNAmental illnessmetabolic ratemitochondrialneonatal brainneurobehavioralneurobiological mechanismneurodevelopmentneuron developmentneuronalneuronal developmentneuronal growthneuropsychiatric diseaseneuropsychiatric disordernewborn childnewborn childrennovelontogenypathophysiologypathwaypeople who are pregnantpharmacologicpregnant femalespregnant motherspregnant peoplepregnant populationspreventpreventingpsychiatric illnesspsychological disorderpsychosocialpublic health relevanceresponseschizophrenicstemsynapse formationsynaptogenesistherapy developmentthose who are pregnantthyroid disorderthyroid functiontranscription factortreatment developmenttreatment effectwomen who are pregnantyoungster
Description preview
ABSTRACT: Globally, iron deficiency (ID) affects 40-50% of pregnant women, fetuses, and children. Fetal-
neonatal ID acutely impairs cognitive, motor and social development in children. More troubling from a public
health perspective is that neurobehavioral deficits persist despite neonatal iron treatment, causing increased risk
of cognitive and…
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