grant
Thyroid Hormone and Neuronal Protection
Organization VA GREATER LOS ANGELES HEALTHCARE SYSTEMLocation LOS ANGELES, UNITED STATESPosted 1 Jan 2014Deadline 31 Mar 2028
VANIHUS FederalResearch GrantFY202521+ years oldATACAcquired brain injuryAdultAdult HumanAnimal ModelAnimal Models and Related StudiesAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAreaBlood SerumBody TissuesBrainBrain EdemaBrain InjuriesBrain Nervous SystemBrain SwellingBrain TraumaBrain regionCell BodyCell Culture TechniquesCell DeathCell LineCell LocomotionCell MigrationCell MovementCell membraneCell modelCellLineCellsCellular MigrationCellular MotilityCellular StressCellular Stress ResponseCellular modelClinicalClinical ResearchClinical StudyCo-cultureCocultivationCocultureCoculture TechniquesControlled StudyCytoplasmic MembraneDNA MethylationDataDeiodinaseDevelopmentDropsyERBA1 Gene ProductsEdemaEncephalonEndocrine TherapyEnzyme GeneEnzymesEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEquilibriumExposure toExpression SignatureGene ExpressionGene Expression ProfileGene TranscriptionGenesGenetic TranscriptionGenomeGliaGlial Cell ProliferationGlial CellsGoalsHeterogeneityHigh PrevalenceHormonal TherapyHortega cellHourHydropsHypoxiaHypoxicImageImpairmentIndividualInflammationInjuryIntermediary MetabolismIntracranial EdemaIodide PeroxidaseIodinaseIodoperoxidase (Heme Type)Iodotyrosine DeiodaseIodotyrosine DeiodinaseKolliker's reticulumL-ThyroxineL-TriiodothyronineLPTNLesionLevothyroxineLinkLiothyronineLocationMapsMediatingMetabolicMetabolic ProcessesMetabolismMethylationMiceMice MammalsMicrogliaModelingModificationMonodeiodinaseMonoiodotyrosine DeiodinaseMorbidityMorbidity - disease rateMurineMusNR1A1 Gene ProductsNatural regenerationNerve CellsNerve RegenerationNerve UnitNeural CellNeuro-regenerationNeurocyteNeurogliaNeuroglial CellsNeuronal DifferentiationNeuronal HypoxiaNeuronal InjuryNeuronsNeuroregenerationNon-neuronal cellNonneuronal cellNuclear ReceptorsO elementO2 elementOxygenOxygen DeficiencyParietal LobePathogenesisPathway interactionsPeripheralPhagocytosisPhenotypePlasma MembranePopulationProcessProliferatingProto-Oncogene Proteins c-erbARNA ExpressionRecombinant TSHRecombinant Thyroid-Stimulating HormoneRecoveryRegenerationResearch SpecimenRodentRodent ModelRodentiaRodents MammalsRoleSCM-1SCM-1aSCM1SCYC1SerumSpecimenStrains Cell LinesSystemT-3T3 Thyroid HormoneT4 Thyroid HormoneTBI recoveryTHRA Gene ProductsTherapeutic LevothyroxineTherapeutic T3Therapeutic TriiodothyronineThyreotropinThyroid Gland HormoneThyroid Hormone ReceptorThyroid HormonesThyroid PeroxidaseThyroid Stimulating HormoneThyroid hormone receptor alphaThyroid hormone receptor αThyroid-Stimulating HormoneThyroperoxidaseThyrotropinThyroxineTimeTissuesTranscriptionTraumatic Brain InjuryTraumatic Brain Injury recoveryTriiodothyronineTyrosine IodinaseVeteransXCL1XCL1 geneadulthoodbalancebalance functionbrain cellbrain damagebrain injury responsebrain-injuredc-erb A Proteinc-erbA Proteinsc-erbA alphac-erbA alpha Proteinc-erbA-1 Proteincell culturecell culturescell motilitycell stresscell typecontrolled cortical impactcultured cell linecytokinedevelopmentalentire genomeepigenetic regulationepigeneticallyerbA Proto-Oncogene Productsfull genomegene expression patterngene expression signaturegenome scalegenome wide methylationgenome-widegenomewidegenomewide methylationgitter cellglial neural stem cellglial progenitorglial stem cellgliogenesisglobal methylationhistone methylationhistone modificationhormone therapyimagingin vitro Modelin vivoinhibitorinjuriesmesogliamicroglial cellmicrogliocytemigrationmilitary veteranmodel of animalmortalitymouse modelmultiomicsmultiple omicsmurine modelnecrocytosisnerve cell deathnerve cell lossnerve cementnervous system regenerationneural regenerationneuroglial progenitorneuroglial stem cellsneuron cell deathneuron cell lossneuron deathneuron injuryneuron lossneuron regenerationneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal growthneuronal lossneuronal regenerationneuroprotectionneuroprotectiveneuroregenerativenovelpanomicsparietal cortexpathogenpathwayperivascular glial cellplasmalemmaprogenitor cell differentiationprogenitor cell migrationprogenitor cell proliferationprogenitor differentiationprogenitor migrationprogenitor proliferationprotective effectrecovery after TBIrecovery after traumatic brain injuryregenerateregenerated nerveresponseresponse to brain injurysocial rolestem and progenitor cell proliferationstem and progenitor differentiationstem cell differentiationstem cell migrationstem cell proliferationtherapeutic targetthyroxintissue repairtranscriptional profiletranscriptional signaturetraumatic brain damageuptakeveteran populationwet brainwhole genome
Description preview
Thyroid hormone (TH) is essential for normal brain development and promotes recovery
and neuronal regeneration after brain injury. TH acts in the brain predominantly through
the nuclear receptor, TH receptor alpha (THRA). Additional factors that impact TH
action in the brain including metabolism, activation of thyroxine (T4) to triiodothyronine…
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