grant
Therapeutic vaccination to boost autologous neutralizing antibodies for ART free HIV Control
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 14 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAIDS preventionAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusActive ImmunizationActive vaccinationAdherenceAfter CareAfter-TreatmentAftercareAnimalsAntibodiesAntibody ResponseAntibody TherapyAntigenic DeterminantsAntigensAutologousAutomationB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBar CodesBindingBinding DeterminantsBiologic ModelsBiological ModelsBloodBlood Reticuloendothelial SystemBody TissuesCell BodyCell LineageCellsCellular Immune FunctionChronicClinical TrialsDNA mutationDataDevelopmentDisease remissionDoseEngineeringEnvironmentEpitopesEvolutionGenetic ChangeGenetic defectGenetic mutationGerm LinesGlycansGoalsHIVHIV PreventionHIV vaccineHIV-1HIV-IHIV/AIDS VaccinesHIV/AIDS preventionHIV1HumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Humoral ImmunitiesImmuneImmune mediated therapyImmunesImmunizationImmunizeImmunologically Directed TherapyImmunotherapyIndividualInfectionInterruptionKineticsKnowledgeLAV-HTLV-IIILymphadenopathy-Associated VirusM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMediatingMessenger RNAMethodsModel SystemModern ManModernizationMolecular InteractionMutationNHP modelsOutcome StudyPersonsPolysaccharidesPopulationPreventionProductionQOLQuality of lifeRegimenRemissionRhesus MacaqueRhesus MonkeySHIVSamplingSystemTechnologyTestingTimeTissuesTranslatingVAC-TXVaccinatedVaccinationVaccine TherapyVaccinesVariantVariationViralViral reservoirVirionVirusVirus ParticleVirus reservoirVirus-HIVWorkantibody based therapiesantibody treatmentantibody-based immunityantibody-based therapeuticsantibody-based treatmentantiretroviral therapyantiretroviral treatmentarmbarcodebooster dosebooster shotbooster vaccinechallenge in rhesus macaquescompare to controlcomparison controlcostdesigndesigningdevelopmentalearly clinical trialearly phase clinical trialexperimentexperimental researchexperimental studyexperimentsflexibilityflexiblegenome mutationhuman immunodeficiency virus vaccineimmune functionimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimmunogenimprovedindividualized strategiesinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinsightlipid based nanoparticlelipid nanoparticlemRNAnano particle deliverynanoparticle deliverednanoparticle deliverynanoparticle therapyneutralizing antibodynon-human primatenonhuman primatenonhuman primate modelsnoveloptimismpassive antibodiespersonalized strategiespositive attitudepost treatmentpreservationrational designresponserhesus challengerhesus macaque challengerhesus monkey infectionside effectsimian HIVsimian human immunodeficiency virussocial stigmastigmatherapeutic immunizationtherapeutic nanoparticlestherapeutic vaccinationtherapeutic vaccinetreatment vaccinesvaccination studyvaccination trialvaccine boostvaccine for the treatmentvaccine for treatmentvaccine strategyvaccine studyvaccine trialviral reboundvirus rebound
Description preview
Summary
Antibody-based approaches to HIV cure or ART-free remission hold promise. Several antibody-based
therapeutic HIV vaccine trials are currently underway, leveraging germline-targeting approaches originally
developed for HIV prevention, which ignore the existing autologous neutralizing antibody (anAb) responses
already present in people with…
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