grant
Therapeutic small molecule modulation of Kv channels
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 1 Apr 2019Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidAcademiaAcidsAminalonAminaloneAnticonvulsant AgentAnticonvulsant DrugsAnticonvulsantsAnticonvulsive AgentsAnticonvulsive DrugsAtaxiaAtaxyBBB crossingBehaviorBody TissuesBrainBrain Nervous SystemCell Membrane LipidsChargeChemical DependenceChemicalsClinical TrialsCocaine AddictionCocaine DependenceCoordination ImpairmentDNA mutationDataDevelopmentDiseaseDisorderDiterpenesDiterpenoidsDoseDrug AddictionDrug DependenceDrug DependencyDrug KineticsDrug TargetingDyssynergiaElectrophysiologyElectrophysiology (science)EncephalonEpilepsyEpileptic SeizuresEpilepticsEpisodic ataxiaFutureGABAGallic acidGenesGenetic ChangeGenetic defectGenetic mutationGenetics-MutagenesisGoalsHMSN Type VHealthHereditary Motor-Sensory Neuropathy with Pyramidal SignsHereditary Spastic ParaplegiaHomoHumanHydroxybenzoic AcidsIn VitroIn vivo analysisIon ChannelIon Channel GatingIon Channel GatingsIonic ChannelsIonsIsoformsK channelK elementKnowledgeKv1.2' channelLeadLigand BindingLigandsLinkLocationMembraneMembrane ChannelsMembrane LipidsMiceMice MammalsModelingModern ManMolecularMolecular Dynamics SimulationMolecular Mechanisms of ActionMovementMurineMusMutagenesisMutagenesis Molecular BiologyMutationNatural ProductsNerve CellsNerve Transmitter SubstancesNerve UnitNervous SystemNeural CellNeurocyteNeurologic Body SystemNeurologic Organ SystemNeuronsNeurophysiology / ElectrophysiologyNeurotransmittersPainPainfulPathogenicityPb elementPharmacokineticsPhasePlantsPotassiumPotassium ChannelPotassium Ion ChannelsProcessProtein IsoformsPsychoactive AgentsPsychoactive CompoundPsychoactive DrugsPsychopharmaceuticalsPsychotropic DrugsPublishingRodentRodentiaRodents MammalsSeizure DisorderSite-Directed MutagenesisSite-Specific MutagenesisSpastic Paraplegia-Hypertrophic Motor-Sensory NeuropathySyndromeTargeted DNA ModificationTargeted ModificationTestingTherapeuticTissuesToxic effectToxicitiesTreatment EfficacyType V Hereditary Motor and Sensory NeuropathyVariantVariationaddicted to cocaineaddictionaddiction to cocaineaddictive disorderblood-brain barrier crossingbloodbrain barrier crossingbody movementcarnosic acidcocaine addictedcocaine seekingdevelop therapydevelopmentaldevelopmental epileptic encephalopathyefficacy testingelectrophysiologicalepilepsiaepileptogenicfunctional restorationgamma-Aminobutyric Acidgenome mutationheavy metal Pbheavy metal leadhuman modelimprovedin vivoin vivo evaluationin vivo testinginterdisciplinary approachintervention developmentintervention efficacyloss of functionmembrane structuremodel of humanmolecular dynamicsmouse modelmultidisciplinary approachmurine modelmutantnaturally occurring productneuronalneuronal excitabilitynew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypre-clinical studypreclinical studyrestore functionrestore functionalityrestore lost functionsafety studysalvinseizure drugseizure medicationsensorsmall moleculesmall molecule therapeuticstherapeutic agent developmenttherapeutic developmenttherapeutic efficacytherapeutic evaluationtherapeutic testingtherapy developmenttherapy efficacytreatment developmentvoltageγ-Aminobutyric Acid
Description preview
Project Summary
Neuronal Kv7 (KCNQ) and Kv1 (KCNA1) subfamily voltage-gated potassium (Kv) channel loss-of-function
causes developmental epileptic encephalopathy, ataxia, hereditary spastic paraplegia (HSP) and addiction. In
this project we focus on the mechanistic basis and potential therapeutic utility of plant-derived diterpenes and…
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