grant
The urothelial glycosaminoglycan layer: composition and contribution to pathogen fitness during catheter-associated urinary tract infection
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 13 Jun 2024Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY20263-D3-Dimensional3DAgeAntibiotic AgentsAntibiotic DrugsAntibioticsApicalArchitectureAssayBacteriaBacterial InfectionsBacteriuriaBasal LayerBindingBioassayBiological AssayBladderBladder Urinary SystemBladder mucosaBody TissuesCSGAGCarbonCatheterizationCathetersCell BodyCell CoatCellsCellular biologyCessation of lifeChondroitinChondroitin SulfatesChondroitinasesDataDeathDeath RateDiseaseDisorderDuran-Reynals Permeability FactorE faecalisE. faecalisEngineering / ArchitectureEnterococcus faecalisEnzyme GeneEnzyme KineticsEnzymesFemaleFutureGL EnzymeGeneralized GrowthGlycocalyxGlycoconjugatesGlycolipidsGlycoproteinsGlycosaminoglycan DegradationGlycosaminoglycan Degradation PathwayGlycosaminoglycansGrowthHPSE ProteinHealthHealth ExpendituresHeparan SulfateHeparanase-1HeparinHeparinic AcidHeparitin SulfateHumanHyaglosidaseHyaluronate 4-glycanohydrolaseHyaluronate HydrolaseHyaluronic AcidHyaluronidaseHyaluronoglucosaminidaseImmuneImmune SurveillanceImmune responseImmunesImmunologic SurveillanceImmunomodulationImmunosurveillanceIndividualInfectionInnate Immune ResponseInterstitial CystitisInterventionInvadedInvestigationKidneyKidney Urinary SystemKnowledgeLifeLyaseLyase GeneMDR organismMDR pathogenMeasuresMembraneMiceMice MammalsMicrobeMiscellaneous AntibioticMissionModelingModern ManMolecular InteractionMonitorMorbidityMucopolysaccharidesMurineMusNational Institutes of HealthOccluding JunctionsOlder PopulationOrganOrganismP mirabilisP. mirabilisPathogenesisPatientsPredispositionPreventionProteoglycanProteus mirabilisPublishingPyelonephritisReceptor ProteinReporterResearchResearch SpecimenResistanceRete MalpighiiRiskRoleS faecalisS. faecalisSeveritiesSeverity of illnessSiteSourceSpecimenStratum BasaleStratum GerminativumStreptococcus Group DStreptococcus faecalisSubstrate SpecificitySulfatasesSurfaceSusceptibilityTestingThickThicknessTight JunctionsTissue GrowthTissuesUPECUnited States National Institutes of HealthUrinary tractUrinary tract infectionUrinary tract infectious diseaseUrineUropathogenUropathogenic E coliUropathogenic E. coliUropathogenic Escherichia coliUrotheliumZonula Occludensage associated differenceage associated effectsage based differenceage dependent differenceage dependent variationage differenceage effectage related differenceage related effectsage related variationage specific differenceagesaging effectanti-microbial agentanti-microbial drugapical membranebacteria infectionbacterial diseasebladder pain syndromecatheter associated UTIcatheter associated urinary tract infectioncell biologychondroitin sulfate glycosaminoglycanco-infectioncoinfectionconstitutive expressionconstitutive gene expressiondamage to kidneydiffer by agedifference across agedifference in agedisease severityexpression vectorfitnesshealth care associated infectionshealth care expenditureheparan sulphate endoglycosidaseheparanasehigh riskhost microbe associationhost microbe relationshiphost responsehost-microbe interactionshost-microbial interactionshost-microorganism interactionshydrogen sulfate Chondroitinimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseimpact of ageimprovedinfection recurrenceinfluence of ageinnovateinnovationinnovativeinsightkidney damagekidney infectionlife spanlifespanliving systemmalemedical expendituremembrane structuremicrobialmortalitymortality ratemouse modelmulti-drug resistant organismmulti-drug resistant pathogenmultidrug resistant organismmultidrug resistant pathogenmultiple drug resistant organismmultiple drug resistant pathogenmurine modelmutantolder adultolder adulthoodolder groupsolder individualsolder personontogenypainful bladder syndromepathogenpatient populationpotential biological markerpotential biomarkerpreventpreventingreceptorrecurrent infectionrecurring infectionrenalrenal damageresistantsexsocial rolethree dimensionalurinaryurinary bladderurinary infectionurinary sepsisurinary tract catheter infectionurosepsisvariation by age♀♂
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Project Summary/Abstract
Urinary tract infection (UTI) is one of the most common infections worldwide and a leading cause of
morbidity and healthcare expenditures across all ages. Older adults and individuals with catheters have a
particularly high risk of UTI sequelae, including kidney infection, permanent renal damage, and urosepsis.
The average…
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