grant
The transcription factor RUNX1 is pivotal in TGFβ-activated cholangiocyte signaling with the immune system in biliary fibrosis
Organization VIRGINIA COMMONWEALTH UNIVERSITYLocation RICHMOND, UNITED STATESPosted 15 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025AML-1AML-1 ProteinAML1 ProteinAttenuatedAutomobile DrivingB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2Basal Transcription FactorBasal transcription factor genesBiliaryBioinformaticsBone-Derived Transforming Growth FactorCBF-Alpha BCCL2CCL2 geneCell BodyCell Communication and SignalingCell DifferentiationCell Differentiation processCell SignalingCell modelCellsCellular modelChIP SequencingChIP-seqChIPseqChemokine, CC Motif, Ligand 2ChemotaxisChronic Non-Suppurative Destructive CholangitisChronic Nonsuppurative Destructive CholangitisCirrhosisClinical TrialsCo-cultureCocultivationCocultureCoculture TechniquesCore-Binding Factor Alpha B SubunitCulturing, in vitro Vertebrate, PrimaryDataDedicationsDevelopmentDietDiseaseDisorderEnzyme GeneEnzymesEpitheliumFibrosisFundingGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGeneticGripsHPGFHepaticHepatobiliaryHepatocyte-Stimulating FactorHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImmuneImmune infiltratesImmune systemImmunesImmunologic StimulationImmunological StimulationImmunologyImmunostimulationIn VitroInflammationInflammatoryInjury to LiverInterleukin-6Intracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLinkLipidsLiverMCAFMCP-1MCP1MGI-2MacrophageMacrophage ActivationMediatingMediatorMentorsMetabolicMiceMice MammalsMilk Growth FactorModelingMolecular TargetMonocyte Chemoattractant Protein-1Monocyte Chemotactic Protein-1Monocyte Chemotactic and Activating FactorMonocyte Chemotactic and Activating ProteinMonocyte Chemotactive and Activating FactorMonocyte Secretory Protein JEMulti-Drug ResistanceMultidrug ResistanceMultiple Drug ResistanceMultiple Drug ResistantMurineMusMyeloid Differentiation-Inducing ProteinMyofibroblastMφNIDDKNational Institute of Diabetes and Digestive and Kidney DiseasesNull MouseOrganPEA2-Alpha BPEBP2-Alpha BPathogenesisPathologic ProcessesPathological ProcessesPathway interactionsPatientsPebp2a2 proteinPhysiciansPlasmacytoma Growth FactorPlatelet Transforming Growth FactorPlayPolyomavirus Enhancer Binding Protein 2 Alpha B SubunitPrimary Cell CulturesPrimary biliary cholangitisPrimary biliary cirrhosisPrincipal InvestigatorProductionResearchResistance to Multi-drugResistance to MultidrugResistance to Multiple DrugResistant to Multiple DrugResistant to multi-drugResistant to multidrugRoleRunt-Related Transcription Factor 1Runx1 proteinSCYA2SL3-3 Enhancer Factor 1 Alpha B SubunitSafetyScientistSignal InductionSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSl3/AKV Core-Binding Factor Alpha B SubunitSmall Inducible Cytokine A2SolidStearate DesaturaseStearoyl-CoA DesaturaseStearyl-CoA DesaturaseTGF BTGF-betaTGF-βTGFbetaTGFβTestingTherapeuticTranscription Factor Proto-OncogeneTranscription factor genesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTranslatingUpregulationValidationacute myeloid leukemia 1 proteinalpha 2 subunit core-binding factorattenuateattenuatesbile ductbile ductulebiological signal transductioncellular differentiationcholangiocytechromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingcirrhoticcore-binding factor alpha 2 proteincytokinedelta-9 Desaturasedevelopmentaldietsdrivingeffective therapyeffective treatmentfat metabolismglobal gene expressionglobal transcription profilegrasphepatic body systemhepatic damagehepatic injuryhepatic organ systemimmune cell infiltratein vivoin vivo Modelinhibitorinnovateinnovationinnovativeinterferon beta 2lipid metabolismlipidomicsliver damageliver injurymetabolism measurementmetabolomicsmetabonomicsmouse modelmulti-drug resistantmultidrug resistantmultiomicsmultiple omicsmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachpanomicspathwaypharmacologicprimary sclerosing cholangitisprogramsrecruitscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstranscription factortranscriptometranscriptomicsvalidations
Description preview
PROJECT SUMMARY/ABSTRACT
Primary sclerosing cholangitis (PSC) and primary biliary cholangitis are characterized by biliary fibrosis, which
involves activated cholangiocyte signaling with immune cells. Insufficient understanding of the transcriptomic
and lipidomic changes in activated cholangiocytes that orchestrate signaling with the immune cells…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click