grant
The Synergistic Effects of Menopause and HIV on Cardiovascular Disease Risk in Women
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Aug 2025Deadline 30 Nov 2030
NIHUS FederalResearch GrantFY202521+ years oldAIDS VirusASCVDAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAdipose tissueAdultAdult HumanAffectAgeAgingAmenorrheaAncillary StudyAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAtherosclerosisAtherosclerotic Cardiovascular DiseaseBMIBMI percentileBMI z-scoreBiological MarkersBiometricsBiometryBiostatisticsBody CompositionBody mass indexCVD preventionCaliforniaCardiovascular DiseasesCategoriesChronic DiseaseChronic IllnessClinicalCohort StudiesConcurrent StudiesConsequences of HIVCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataData AnalysesData AnalysisDevelopmentDiabetes MellitusDisease Frequency SurveysDysfunctionEndocrine TherapyEstrogensEventFatty TissueFunctional disorderFundingGoalsHIVHIV InfectionsHTLV-III InfectionsHTLV-III-LAV InfectionsHealth PrioritiesHormonalHormonal TherapyHuman Immunodeficiency VirusesHuman T-Lymphotropic Virus Type III InfectionsHypertensionImageImmune Cell ActivationImmune MarkersImmunologic MarkersInflammatoryInsulin ResistanceInterventionInvestigatorsLAV-HTLV-IIILipidsLipoproteinsLymphadenopathy-Associated VirusMR ImagingMR TomographyMRIMRIsMacrophage ActivationMagnetic Resonance ImagingMeasurementMeasuresMediatingMediationMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedicineMenopauseMensesMenstruationMentorshipModelingMuellerian inhibiting hormoneMullerian-inhibiting factorNHLBINMR ImagingNMR TomographyNational Heart, Lung, and Blood InstituteNegotiatingNegotiationNuclear Magnetic Resonance ImagingObesityOrganOutcomeOvarian agingPathway interactionsPatient Self-ReportPatient imagingPerimenopausalPerimenopausePhasePhysiopathologyPost-MenopausePost-menopausal PeriodPostmenopausal PeriodPostmenopausePre-MenopausePre-menopausal PeriodPremenopausalPremenopausal PeriodPremenopausePreventative interventionPreventative strategyPrevention strategyPreventive strategyProbabilistic ModelsProbability ModelsQuetelet indexResearch PersonnelResearchersRiskRisk FactorsRoleSan FranciscoSelf-ReportSiteStatistical ModelsTestingTherapeutic EstrogenTherapeutic InterventionTimeTrainingUnited StatesUniversitiesVascular Hypertensive DiseaseVascular Hypertensive DisorderVirus-HIVVisceralWomanWomen's studyZeugmatographyadiposeadiposityadulthoodafter menopauseagesaging associatedaging human ovaryaging ovaryaging relatedameniaanalyzing longitudinalanti-mullerian factoranti-mullerian hormoneantiretroviral therapyantiretroviral treatmentatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebio-markersbiologic markerbiomarkerbiomedical imagingcardiac disease preventioncardiometaboliccardiometabolismcardiovascular disease preventioncardiovascular disease riskcardiovascular disordercardiovascular disorder preventioncardiovascular disorder riskcareercareer developmentcarotid intima-media thicknesschronic disorderco-morbidco-morbiditycohortcomorbiditycorpulencecritical perioddata interpretationdata modelingdevelopmentaldiabetesexperiencefemale studyfollowing menopausegirlshigh blood pressurehormone therapyhyperpiesiahyperpiesishypertensive diseasehypertensive disorderimage-based methodimagingimaging in patientsimaging methodimaging modalityimaging on patientsimmune activationimmune-based biomarkersimmunological biomarkersimmunological markersinsulin resistantinsulin toleranceintervention for preventionintervention therapyintima medialongitudinal analysismenopause transitionmenstrual periodmid lifemid-lifemiddle agemiddle agedmidlifemodel of datamodel the datamodeling of the datamonthly periodmonthly periodsmullerian inhibiting substancemullerian regression factormullerian-inhibiting hormonemullerian-inhibitory substancemultimorbiditymultiple chronic conditionsovarian reserveovarian senescenceovulatory senescencepast menopausepathophysiologypathwaypatient oriented researchpatient oriented studyperi-menopausalperi-menopausepost-menopausalpostmenopausalpostmenopausal statuspre-menopausalpremenopausal statuspreventpreventingprevention interventionpreventional intervention strategypreventive interventionprofessorscreeningscreeningssecondary analysissocial rolestatistical linear mixed modelsstatistical linear modelsstudy among femalesstudy among womenstudy in femalesstudy in womenstudy on femalesstudy on womenstudy within womensubcutaneoussubdermaltherapeutic targettransition to menopausetransitional menopausewaist circumferencewhite adipose tissueyellow adipose tissue
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Project Summary/Abstract
Understanding the contribution of menopause to clinical outcomes in HIV is an emerging health priority. There
are over 20 million girls and women living with HIV (WWH) worldwide and over 50% of WWH in the US are
experiencing the transition to menopause, a multi-year period characterized by declines in ovarian reserve that…
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