grant
The roles of Rett Syndrome protein MECP2 at gene regulatory elements
Organization UT SOUTHWESTERN MEDICAL CENTERLocation DALLAS, UNITED STATESPosted 5 Mar 2026Deadline 31 Dec 2030
NIHUS FederalResearch GrantFY202621+ years oldAdultAdult HumanAffinityBehavioralBindingBinding SitesBody TissuesBrainBrain Nervous SystemCausalityCell BodyCellsCerebroatrophic HyperammonemiaCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCombining SiteComplexDNA Binding DomainDNA MethylationDNA SequenceDNA mutationDNA-Binding Protein MotifsDataDefectDiseaseDisorderDisturbance in cognitionElementsEncephalonEnhancersEtiologyExhibitsGene Action RegulationGene Down-RegulationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGeneticGenetic ChangeGenetic DiversityGenetic TranscriptionGenetic VariationGenetic defectGenetic mutationGenomeGenomicsHDACHDAC ProteinsHistone DeacetylaseImpaired cognitionIn VitroInbreedingIncubatedIon ChannelIonic ChannelsKO miceKnock-out MiceKnockout MiceLeadLibrariesMeCP-2 proteinMeCP2MeCP2 proteinMediatingMembrane ChannelsMethyl CpG binding protein MeCP2Methyl-CpG-Binding Protein 2Methyl-DNA binding protein MECP2MethylationMiceMice MammalsModelingMolecularMolecular InteractionMurineMusMutationN-CoR proteinNCOR1NCOR1 geneNCoR proteinNamesNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeurocyteNeurodevelopmental DisorderNeurologic DisordersNeurological Development DisorderNeurological DisordersNeuronsNuclear Receptor Co-Repressor 2Nuclear Receptor Corepressor 1Null MouseOligoOligonucleotidesPatientsPatternPb elementPhenotypePhosphorylationProtein Binding DomainProtein Binding MotifProtein PhosphorylationProtein-Protein Interaction DomainProteinsRIP13 proteinRNA ExpressionReactive SiteRecombinantsRecruitment ActivityRegulatory ElementRepressionRett DisorderRett SyndromeRoleSMRT proteinSPRET/EiJ MouseSilencing Mediator of Retinoic Acid and Thyroid Hormone ReceptorsSiteSymptomsSynapsesSynapticT3 Receptor-associating FactorTestingTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscription RepressionTranscriptional ControlTranscriptional RegulationVariantVariationViralWorkactive recruitmentadulthoodanalyze gene expressioncausationcognitive dysfunctioncognitive lossderepressiondisease causationexperimentexperimental researchexperimental studyexperimentsgene expression analysisgene expression assaygene repressiongenetic approachgenetic strategygenome mutationheavy metal Pbheavy metal leadin vivoinsightmotor impairmentmovement impairmentmovement limitationmutantnamenamednamingneuralneurodevelopmental diseaseneurological diseaseneuronalnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetnuclear corepressor 2nuclear receptor co-repressoroligosprotein expressionrecruitrestorationsocial rolesynapsetranscriptional profiling
Description preview
Project Summary:
Rett Syndrome (RTT) is a progressive neurological disorder characterized by severe cognitive and motor
impairments caused primarily by mutations in MECP2. The molecular mechanisms by which disruption of
MECP2 gives rise to RTT remain unclear. MECP2 is known to bind to methylated DNA in the brain, regulating
the expression of…
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