grant
The Role of Vitamin D Deficiency-induced Macrophage Renin Angiotensin System Activation in the Development of Hypertension
Organization ST. LOUIS VA MEDICAL CENTERLocation St. Louis, UNITED STATESPosted 1 Jan 2024Deadline 31 Dec 2028
VANIHUS FederalResearch GrantFY20251,25-Dihydroxycholecalciferol Receptors1,25-Dihydroxyvitamin D 3 Receptors1,25-Dihydroxyvitamin D3 ReceptorsAcademic skillsAddressAdvisory CommitteesAngiotensin-Forming EnzymeAngiotensinogenaseApoplexyAutomobile DrivingAwardBP homeostasisBP regulationBlood PressureBody TissuesBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationBrain Vascular AccidentCalcitriol ReceptorsCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell SignalingCellsCellular Immune FunctionCellular biologyCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCholecalciferol ReceptorsChronic DiseaseChronic IllnessColoradoDevelopmentDoctor of MedicineDoctor of PhilosophyDrugsEndocrineEndocrinologyEnsureFellowshipGene TranscriptionGenetic TranscriptionGoalsGrantHealth Care SystemsHeart VascularHumanHypertensionImmuneImmunesImmunologyImmunomodulationImpairmentInflammatoryInternal MedicineIntracellular Communication and SignalingIsraelKO miceKnock-out MiceKnockout MiceKnowledgeLaboratoriesM.D.MacrophageMarrow TransplantationMediatingMedical centerMedicationMedicineMentorsMetabolic DiseasesMetabolic DisorderMetabolism and EndocrinologyMiceMice MammalsModern ManMonitorMurineMusMφNuclear Hormone Receptor SuperfamilyNuclear Hormone ReceptorsNull MouseOutcomePh.D.PhDPharmaceutical PreparationsPhenotypePhysiciansPhysiologicPhysiologicalProductionPublishingRNA ExpressionRegimenReninRenin-Angiotensin SystemResearchResidenciesRisk ReductionRoleScientistSignal TransductionSignal Transduction SystemsSignalingStrokeSystemic blood pressureSystemic hypertensionTask ForcesTestingThesaurismosisTissuesTrainingTranscriptionUniversitiesUpregulationVIT DVascular Hypertensive DiseaseVascular Hypertensive DisorderVeteransVitamin DVitamin D 3 ReceptorsVitamin D DeficiencyVitamin D ReceptorsVitamin D3 ReceptorWashingtonWorkWritingadvisory teambiological signal transductionblood pressure homeostasisblood pressure regulationbrain attackcardiometaboliccardiometabolismcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcareercareer developmentcell biologycerebral vascular accidentcerebrovascular accidentchronic disordercirculatory systemconferenceconventiondevelopmentaldrivingdrug/agentexperienceexperimentexperimental researchexperimental studyexperimentshigh blood pressurehyperpiesiahyperpiesishypertension controlhypertension managementhypertensive diseasehypertensive disorderimmune functionimmune modulationimmune regulationimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryinstructormedical collegemedical schoolsmetabolic phenotypemetabolism disordermetabotypemilitary veteranmouse modelmurine modelnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachprogramsreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskregulate BPregulate blood pressurerisk-reducingschool of medicineskillssocial rolestrokedstrokessummitsymposiasymposiumsystemic inflammationsystemic inflammatory responsetranslational therapeuticstranslational therapyveteran population
Description preview
RESEARCH STRATEGY: The objective of this proposal is to delineate the mechanisms by which macrophage
renin signaling contributes to the development of hypertension (HTN) associated with disrupted vitamin D (VD)
signaling. HTN is the most common chronic disease in the veteran population and associated with an increased
risk of cardiovascular…
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