grant
The Role of the Gut Microbiome in Post-Sepsis Skeletal Muscle Atrophy
Organization UNIVERSITY OF IOWALocation IOWA CITY, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2026AffectAnabolismAnimal ModelAnimal Models and Related StudiesAntibiotic AgentsAntibiotic DrugsAntibiotic TherapyAntibiotic TreatmentAntibioticsAtrophicAtrophyAwardBacteriaBiologyBionomicsBloodBlood Reticuloendothelial SystemBody TissuesCalibrationCessation of lifeComplementComplement ProteinsCritical CareCritical IllnessCritically IllDataDeathDebilityDevelopmentDevelopment PlansDoctor of MedicineDoctor of PharmacyDoctor of PhilosophyDrug TherapyDysfunctionEarly InterventionEcologyFinancial costFive-Year PlansFoundationsFunctional MetagenomicsFunctional disorderFutureGI microbiomeGI microbiotaGastrointestinal microbiotaGene ExpressionGerm-FreeGoalsHealthHospital AdmissionHospitalizationHumanHypertrophyImmuneImmunesIn VitroInfectionIntestinalIntestinesInvestigationInvestigatorsKaleKale - dietaryLeftLower GI TractLower Gastrointestinal TractM.D.MeasuresMediatingMediatorMedicalMedicineMentorsMentorshipMetabolicMetabolic PathwayMetagenomicsMiceMice MammalsMichiganMicrobiomicsMiscellaneous AntibioticModern ManMorbidityMurineMusMuscleMuscle AtrophyMuscle FibersMuscle TissueMuscle WeaknessMuscular AtrophyMuscular WeaknessMyotubesObesityOrganOutcomeOutputPathogenesisPatientsPh.D.PhDPharm.D.PharmDPharmacological TreatmentPharmacotherapyPhysical RehabilitationPhysiciansPhysiopathologyPlayProductivityPublishingQOLQuality of lifeRegulationResearchResearch PersonnelResearchersRhabdomyocyteRiskRoleScientistSecondary toSepsisSeveritiesShort-Chain Fatty AcidsSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSupplementationSurvivorsSwabTechniquesTestingTherapeuticTissuesTrainingTranslatingUnited StatesUniversitiesVariantVariationVolatile Fatty AcidsVoluntary MuscleWorkadiposityafter sepsisafter septicantisepsis treatmentbacteria in the gutbacterial disease treatmentbacterial infectious disease treatmentbiosynthesisbowelcareer developmentcomplementationcorpulencedevelopmentaldigestive tract microbiomedrug interventiondrug treatmentendurance exerciseenteric microbial communityenteric microbiomeenteric microbiotaexercise capacityexperienceexperimentexperimental researchexperimental studyexperimentsfollowing sepsisfollowing septicgastrointestinal microbial floragastrointestinal microbiomegut bacteriagut communitygut floragut microbe communitygut microbesgut microbial communitygut microbial compositiongut microbial consortiagut microbial speciesgut microbiomegut microbiotagut microbioticgut microfloragut-associated microbiomeimprovedin vitro Modelin vivoin vivo Modelintestinal biomeintestinal floraintestinal microbesintestinal microbiomeintestinal microbiotaintestinal microfloraintestinal tract microflorametabolism measurementmetabolomicsmetabonomicsmicrobialmicrobiomemicrobiome researchmicrobiome sciencemicrobiome studiesmodel of animalmonetary costmortalitymouse modelmurine modelmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle metabolismmuscle physiologymuscle wastingmuscularpathophysiologypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphysical rehabpost sepsispost septicpost-doctoral trainingpreventpreventingpulmonaryresponsesepsis caresepsis interventionssepsis managementsepsis survivorsepsis survivorshipsepsis therapeuticssepsis therapysepsis treatmentseptic survivalseptic survivorseptic therapyseptic treatmentskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle protein lossskeletal muscle wastingskill acquisitionskill developmentskillssocial rolesuccesssurvive sepsistreat sepsis
Description preview
PROJECT SUMMARY
This K08 proposal outlines the plan for Kale Bongers, M.D. Ph.D.’s to complete training toward his long-term
goal of improving our understanding of post-sepsis muscle atrophy and weakness through investigation of the
microbiome. Dr. Bongers is a physician-scientist in Pulmonary and Critical Care Medicine at the University of…
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