grant
The Role of Tension Anisotropy in Fibroblast Activation
Organization NEW JERSEY INSTITUTE OF TECHNOLOGYLocation NEWARK, UNITED STATESPosted 1 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY2025Abnormal CellActin-Activated ATPaseActinsAffectAgingAnimal ExperimentsAnimal ModelAnimal Models and Related StudiesAnimalsAnisotropyAreaBenchmarkingBest Practice AnalysisBody TissuesCell BodyCell Communication and SignalingCell LocomotionCell MigrationCell MovementCell ShapeCell SignalingCell modelCell-Extracellular MatrixCellsCellular MatrixCellular MigrationCellular MotilityCellular modelChondrocytesClinicalCollagenContractureCuesCytoskeletal SystemCytoskeletonDataDermalDiseaseDisorderECMEnvironmentExtracellular MatrixFibroblastsFibrosisFutureGenerationsGrafting ProcedureHarvestIn VitroIntracellular Communication and SignalingInvestigationIsometric ExerciseIsometricsKnowledgeLengthMalignant Skin NeoplasmMeasurementMechanical StressMechanicsMemoryMetastasisMetastasizeMetastatic LesionMetastatic MassMetastatic NeoplasmMetastatic TumorMuscle-Setting ExerciseMyosin ATPaseMyosin Adenosine TriphosphataseMyosin AdenosinetriphosphataseMyosinsNatureNeoplasm MetastasisOperative ProceduresOperative Surgical ProceduresOrgan TransplantationOrgan TransplantsOsteoblastsOutcomeOutcome MeasurePathologicPatternPlayPostoperative ComplicationsProcessPropertyProtocolProtocols documentationPublishingReportingResearch SpecimenRiskRoleSecondary NeoplasmSecondary TumorSeriesSignal TransductionSignal Transduction SystemsSignalingSiteSkinSkin CancerSkin graftSpecimenStatic ExerciseStressStretchingStructureSurgicalSurgical InterventionsSurgical ProcedureTechniquesTechnologyTestingTheoretical StudiesTherapeuticThickThicknessTissue ModelTissuesTransmissionTransplantationUpregulationValidationWorkallogenic skin graftanimal experimentbenchmarkbiological adaptation to stressbiological signal transductioncancer metastasiscell motilitydesigndesigningexperienceexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentsextracellularimprovedin vitro Modelin vivoinsightintracellular skeletonmalignant skin tumormeasurable outcomemechanicmechanicalmechanical cuemechanical signalmechanical stimulusmembermemory retentionmodel of animalnovelorgan allograftorgan graftorgan xenograftoutcome measurementpost-operative complicationspreventpreventingreaction; crisisresponsesocial rolestress reductionstress responsestress; reactionsuccesssurgerytissue repairtissue woundtooltransmission processtransplanttumor cell metastasisvalidationsviscoelasticitywoundwound closurewoundingwounds
Description preview
Project Summary
Fibroblasts play a crucial role in tissue function by generating and modulating contractile forces in response to
environmental cues. Upon activation, they upregulate actin and myosin to enhance contractile force generation,
a process vital for wound closure and tissue repair. However, prolonged fibroblast activation can lead to…
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