grant
The role of T cell derived cytokines in Helicobacter pylori and other gastrointestinal infections.
Organization VETERANS HEALTH ADMINISTRATIONLocation NASHVILLE, UNITED STATESPosted 1 Jun 2025Deadline 31 May 2031
VANIHUS FederalResearch GrantFY2026Ab responseAgingAnimal ModelAnimal Models and Related StudiesAntibiotic TherapyAntibiotic TreatmentAntibodiesAntibody FormationAntibody ProductionAntigen PresentationAntigen-Presenting CellsAreaAssayAtlasesB blood cellsB cellB cellsB fragilisB-CellsB-LymphocytesB-cellB. fragilisBacteriaBacterial InfectionsBacteroides fragilisBioassayBiological AssayBody TissuesC fusiformeC pyloriC. fusiformeC. pyloriCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCTLA-8CTLA-8 GeneCTLA8CTLA8 GeneCampylobacter pyloriCancer Causing AgentsCancer InductionCancer TreatmentCancersCarcinogensCell BodyCell Communication and SignalingCell SignalingCellsChronicCo-cultureCocultivationCocultureCoculture TechniquesColon or RectumColorectalColorectal CancerCorynebacterium fusiformeCytotoxic T-Lymphocyte-Associated Antigen 8Cytotoxic T-Lymphocyte-Associated Antigen 8 GeneCytotoxic T-Lymphocyte-Associated Serine Esterase 8Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 GeneDataDevelopmentDysplasiaE coliE. coliEarly DiagnosisEpithelial CellsEquilibriumEscherichia coliExhibitsExposure toF fusiformisF nucleatumF nucleatusF. fusiformisF. nucleatumF. nucleatusFibroblastsFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFusiformis fusiformisFusiformis nucleatusFusobacterium nucleatumGI cancersGI malignanciesGI tract cancersGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric Pylorus CancerGastric TissueGastrointestinal CancerGastrointestinal Tract CancerGenesGerm LinesGulf WarH pyloriH pylori infectionH pyloryH. pyloriH. pylori infectionH. pyloryHealth CareHelicobacter InfectionsHelicobacter Pylori InfectionHelicobacter pyloriHost FactorHost Factor ProteinHumanIL-17IL-17 GeneIL-17AIL-17A GeneIL17IL17 ProteinIL17 geneIL17AIL17A GeneIL21ImageImmuneImmune Cell ActivationImmune mediated therapyImmune responseImmunesImmunologically Directed TherapyImmunotherapeutic agentImmunotherapyIn VitroIndolentInfectionInfection ControlInflammationInflammatoryInflammatory ResponseInjuryIntegration Host FactorsInterleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) GeneInterleukin 17 PrecursorInterleukin 17 Precursor GeneInterleukin-17Intracellular Communication and SignalingIonizing Electromagnetic RadiationIonizing radiationLaboratoriesLinkLong-term infectionLymphoid FollicleMaintenanceMalignant Gastric NeoplasmMalignant Gastric TumorMalignant Gastrointestinal NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMalignant NeoplasmsMalignant TumorMalignant neoplasm of gastrointestinal tractMiceMice MammalsModelingModern ManMucinsMucus GlycoproteinMurineMusOncogensOperation Desert ShieldOperation Desert StormOrganoidsOutcomePD-1 antibodyPD1 antibodyParasitesPathogenesisPathologicPathway interactionsPharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePhenotypePlayPositionPositioning AttributeProcessPrognostic MarkerProteinsPublishingRadiation-Ionizing TotalReceptor ProteinRisk FactorsRoleServicesSignal TransductionSignal Transduction SystemsSignalingStomachStomach CancerSurvival RateT cell responseT-CellsT-LymphocyteT4 CellsT4 LymphocytesTCGATestingThe Cancer Genome AtlasTissuesTranslationsVeteransVirusWorkaPD-1aPD1accessory cellanti programmed cell death 1anti-PD-1anti-PD-1 Abanti-PD-1 antibodiesanti-PD-1 monoclonal antibodiesanti-PD1anti-PD1 Abanti-PD1 antibodiesanti-PD1 monoclonal antibodiesanti-cancer therapyanti-microbialanti-programmed cell death protein 1anti-programmed cell death protein 1 antibodiesanti-programmed death-1 antibodyantiPD-1antibody biosynthesisantigen-specific T cellsantimicrobialbacteria infectionbacterial diseasebacterial disease treatmentbacterial infectious disease treatmentbalancebalance functionbiological signal transductionbiomarker developmentcancer diagnosiscancer survivalcancer therapycancer-directed therapycarcinogenesiscarcinogenicitychronic infectionclinical relevanceclinical significanceclinically relevantclinically significantcolorectumcytokinedesigndesigningdevelopmentaldyscrasiaearly detectionexperienceflow cytophotometrygastricgastric cancer preventiongastric malignancygastric organoidsgastroidgastrointestinal infectiongastrointestinal malignancieshealinghost responseimagingimmune activationimmune drugsimmune system responseimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunoglobulin biosynthesisimmunologic therapeuticsimmunoresponseimmunotherapeuticsimmunotherapy agentimprovedin vivoinjuriesinnovateinnovationinnovativeinterleukin-21ionizing outputlenslensesmalignancymalignant stomach neoplasmmalignant stomach tumormilitary membermodel of animalmouse modelmurine modelneoplasm/cancerneutralizing antibodynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachoncogenic agentpathogenpathwaypersistent infectionpharmaceuticalpreventprevent gastric cancerprevent stomach cancerpreventingprognostic biomarkerprognostic indicatorreceptorreconstitutereconstitutionrecruitrepairrepairedresponserestorationrisk stratificationservice membersocial rolestomach cancer preventionstomach fundus cancerstomach organoidstomach pylorus cancerstratify riskthymus derived lymphocytetissue repairtooltool developmenttranscriptomicstranslationtreatment strategytumorαPD-1αPD1
Description preview
Project Summary
Background and Innovation. Chronic infections and the inflammation associated with long-term immune
activation contribute to carcinogenesis in several tissues, especially gastrointestinal infections. Specifically,
Helicobacter pylori infection has been formally recognized as a Type I carcinogen for over many years. More
recently,…
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