grant
The role of serpins and LRP1 in the esophageal epithelium during eosinophilic esophagitis
Organization CINCINNATI CHILDRENS HOSP MED CTRLocation CINCINNATI, UNITED STATESPosted 1 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY20250-11 years oldAffectAgonistAllergensAllergicAllergic DiseaseAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAntigensAntiinflammatory EffectAntiproteasesApo E ReceptorApoE ReceptorApolipoprotein E ReceptorAttenuatedAutoregulationBindingBiopsyBody TissuesC-terminalCa2+-Activated ProteaseCalcium-Activated Neutral ProteaseCalcium-Activated Neutral ProteinaseCalcium-Activated ProteaseCalcium-Dependent Neutral ProteaseCalcium-Dependent Neutral ProteinaseCalpainCaspaseCaspase GeneCausalityCell BodyCell Communication and SignalingCell SignalingCell-Death ProteaseCellsChildChild YouthChildhoodChildren (0-21)ChronicComplexCysteine EndopeptidasesCysteine ProteaseCysteine ProteinasesD12S1644Deglutition DisordersDependenceDesminaseDetergentsDevelopmentDiseaseDisorderDrugsDysfunctionDysphagiaEndopeptidase InhibitorsEnvironmentEnzyme GeneEnzymesEosinophiliaEosinophilic EsophagitisEpithelial CellsEpitheliumEquationEquilibriumEsophageal DiseasesEsophageal DisorderEsophagusEsteroproteasesEtiologyFoodFoundationsFunctional disorderGene ExpressionGene TranscriptionGenesGenetic TranscriptionGoalsHomeostasisICE-like proteaseIL-13IL-4-STATIL13ImmuneImmune ToleranceImmunesImmunityImmunologic ToleranceIn VitroIndividualInflammationInflammatoryInflammatory ResponseInterleukin-13Intracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLDL-Receptor Related Protein 1LengthLigandsLipoprotein ReceptorLocationLow Density Lipoprotein Receptor-Related ProteinLow-Density-Lipoprotein Receptor-Related Protein-1MediatingMediatorMedicationModelingMolecularMolecular InteractionMolecular WeightNuclearNull MousePainPainfulPapain-Like Cysteine ProteasePathogenesisPathologyPatientsPenetrationPeptidase InhibitorsPeptidasesPeptide Hydrolase InhibitorsPeptide HydrolasesPeptide Peptidohydrolase InhibitorsPeptidesPharmaceutical PreparationsPhenotypePhosphorylationPhysiologicPhysiologicalPhysiological HomeostasisPhysiopathologyPlayProcessProductionProtease AntagonistsProtease GeneProtease InhibitorProteasesProtein PhosphorylationProteinase InhibitorsProteinasesProteinsProteolytic EnzymesQOLQuality of lifeRNA ExpressionReactionResolutionRoleSTAT6STAT6 geneSTAT6BSTAT6CSeriesSerine Endopeptidase InhibitorsSerine Protease InhibitorsSerine Proteinase AntagonistsSerine Proteinase InhibitorsSerpinsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteStimulusSwallowing DisordersTSLPTSLP geneTestingTherapeuticTherapeutic EffectThymic Stromal LymphopoietinTissuesTranscriptionTranslatingacetyl-LDL receptoracetylated LDL receptorallergen responseallergic responseallergy responsealpha-2-Macroglobulin Receptoralpha2-Macroglobulin Signaling Receptoranti-inflammatory effectattenuateattenuatesbalancebalance functionbiological signal transductioncausationcystein proteasecystein proteinasecysteine endopeptidasedevelopmentaldisease causationdiseases of esophagusdrug/agentencryptionesophagus disordergene signaturesgenetic signaturehuman subjectimmune system toleranceimmune unresponsivenessimmunogenimmunological paralysisimprovedin vivoinsightinterleukin-4 Statkidsmouse modelmurine modelpathophysiologypediatricpre-clinicalpreclinicalpreservationreceptor mediated endocytosisresolutionsresponsescavenger receptorsmall molecular inhibitorsmall molecule inhibitorsocial roletherapeutic targetyoungster
Description preview
PROJECT SUMMRAY
Eosinophilic esophagitis (EoE) is a chronic allergic disease of the esophagus, partly mediated by type 2 immunity
and epithelial dysfunction. Patients with EoE suffer from dysphagia, pain, and the lowest quality of life among
children with chronic, pediatric conditions. The epithelium is the first line of defense against potential…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click