grant
The Role of Parabrachial CGRP Neurons in Opioid Reinforcement
Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AbstinenceAddressAdrenergic AntagonistsAdrenergic BlockadersAdrenergic BlockersAdrenergic Receptor AntagonistsAdrenergic Receptor BlockadersAdrenergic-Blocking AgentsAdrenolytic AgentsAdrenolytic DrugsAdrenolyticsAffectAlcohol withdrawal syndromeAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnatomic SitesAnatomic structuresAnatomyAnti-AdrenergicsAnti-adrenergic AgentsAntiadrenergic AgentsAntiadrenergicsAutomobile DrivingBehaviorBehavioralBehavioral ParadigmBioinformaticsBrain regionCalcitonin Gene-Related PeptideCell BodyCellsChromatinChronicClinical TrialsDangerousnessDataDiseaseDisorderDrug TargetingDrug usageDrugsEmotionalEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExpression SignatureFDA approvedGene ExpressionGene Expression ProfileGenesGeneticGlutamatesIndividualInfumorphInterventionIntravenousItchingKadianL-GlutamateMS ContinMSirMaintenanceMapsMedicationMiceMice MammalsMigraineMigraine HeadacheModelingMolecularMolecular FingerprintingMolecular ProfilingMolecular TargetMorphiaMorphineMotivationMurineMusNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeuronal TransmissionNeuronsNeuropeptidesNuclearOpiate AddictionOpiate DependenceOpiate ReceptorsOpiatesOpioidOpioid ReceptorOramorphOramorph SRPainPainfulPatientsPeptide Signal SequencesPeptide-based drugPharmaceutical PreparationsPopulationPositionPositioning AttributePredispositionPruritic DisorderPruritisPruritusPsychological reinforcementPublic HealthRNA SeqRNA sequencingRNAseqRecurrent diseaseReinforcementRelapseRelapsed DiseaseRoleRoxanolSelf AdministeredSelf AdministrationShapesSignal PeptideSignal SequencesStaining methodStainsStatex SRSubstance abuse problemSusceptibilityTechniquesTestingTherapeuticTrainingTransmissionWithdrawalabuse of substancesalcohol withdrawalamygdaloid nuclear complexaxon signalingaxon-glial signalingaxonal signalingdifferential expressiondifferentially expresseddrivingdrug rewarddrug usedrug withdrawaldrug/agentepigeneticallyepigenomicsethanol withdrawalexperiencegene expression patterngene expression signatureglia signalingglial signalingglobal gene expressionglobal transcription profileglutamatergichistone modificationinhibitorinterestitch sensationlofexidinelong-term abstinencemedication-assisted therapymedication-assisted treatmentmigraine therapymigraine treatmentmolecular profilemolecular signaturenegative affectnegative affectivitynerve signalingneural signalingneuronalneuronal signalingneurotransmissionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnon-narcotic analgesicnon-opiate analgesicnon-opioidnon-opioid analgesicnon-opioid therapeuticsnonnarcotic analgesicsnonopiate analgesicnonopioidnonopioid analgesicsnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetopiate crisisopiate use disorderopiate withdrawalopioid addictionopioid crisisopioid dependenceopioid dependentopioid detoxopioid detoxificationopioid epidemicopioid use disorderopioid withdrawalparabrachial nucleuspeptide drugperipheral painpharmacologicprevent relapseprotein signal sequencerelapse preventionresponsesocial rolesubstance abusetherapeutic peptidetherapeutically effectivetranscriptional differencestranscriptional profiletranscriptional signaturetranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstransmission processwithdrawal from alcohol
Description preview
PROJECT SUMMARY
Opioid Use Disorder (OUD) is a chronic, relapsing disease that, despite our best efforts to understand and
mitigate the disease, has become a worsening public health crisis. 1,2 Currently, the medications to treat OUD
interact directly with opioid receptors. 3 While this helps patients decrease the use of more dangerous opioids,…
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