grant
The Role of Pain-Facilitating Circuits in Chronic Pain after Traumatic Brain Injury
Organization VETERANS ADMIN PALO ALTO HEALTH CARE SYSLocation PALO ALTO, UNITED STATESPosted 1 Oct 2024Deadline 30 Sept 2029
VANIHUS FederalResearch GrantFY2026AcuteAddressAffectAnimalsApplied GeneticsAttenuatedAwardBehavioral ModelBrain ConcussionBrain StemBrain TraumaBrainstemCalciumCell BodyCellsCephalalgiaCephalgiaCephalodyniaCerebral ConcussionChronic pain syndromeClinical DataClinical ResearchClinical StudyCommotio CerebriComplementComplement ProteinsCranial PainCraniocerebral InjuriesCraniocerebral TraumaDREADDsDataDevelopmentDysfunctionExhibitsExposure toFeedbackFiberFunctional disorderFundingGeneticGenetic TechnicsGenetic TechniquesGoalsGulf War IllnessGulf War SyndromeHead InjuriesHead PainHead TraumaHeadacheHealthHealth CareHypersensitivityImageInjuryInvestigatorsKnowledgeLaboratory StudyLesionLightLinkLong-term painMTBIMaintenanceMechanicsMediatingMedical RehabilitationMentorshipMethodsMiceMice MammalsModelingMurineMusNational Institutes of HealthNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeurosciencesNociceptionOperative ProceduresOperative Surgical ProceduresOtomyOutputPainPain ControlPain ResearchPain TherapyPain managementPainfulPatientsPatients with traumatic brain injuryPersian Gulf SyndromePersistent painPhotometryPhotoradiationPhysiopathologyPost-operative PainPostoperative PainProcessPublic HealthQOLQuality of lifeRehabilitationRehabilitation therapyResearchResearch PersonnelResearchersRoleScientistSpecialistSpinalStimulusStressSurgicalSurgical InterventionsSurgical ProcedureSurgical incisionsSystemTBI PatientsTestingTimeTrainingTransfectionTransgenic MiceTransmissionTraumatic Brain InjuryTrigeminal SystemUnited States National Institutes of HealthVeteransWithdrawalallodyniaattenuateattenuatesbehavior studybehavioral sensitizationbehavioral studycareercentral paincentral pain syndromecentral sensitizationchronic painchronic pain conditionchronic pain disorderchronic painful conditionclinical relevanceclinical significanceclinically relevantclinically significantcomplementationconcussionconcussiveconditioned place preferenceconstant paincortical paindesigndesigner receptors exclusively activated by designer drugsdesigningdevelop therapydevelopmentaldisabilitydorsal horneffective therapyeffective treatmentenvironmental stressesenvironmental stressorexperimentexperimental researchexperimental studyexperimentsfunctional outcomeshead acheimagingimprovedin vivoincisioninhibit paininjuriesinsightintervention developmentlasting painmechanicmechanicalmechanical stimulusmild TBImild brain traumamild traumatic brain injurymouse modelmu opioid receptorsmurine modelneuronalneurophysiologicalneurophysiologyneurotoxicnociceptivenon-medical opioid usenonmedical opioid usenovelon-going painongoing painopiate misuseopioid misuseopioid sparingpain after surgerypain behaviorpain inhibitionpain interventionpain sensitivitypain treatmentpathophysiologyplace conditioningpost-surgical painpostsurgical painpreventpreventingprogramsreceptor expressionrehab strategyrehab therapyrehabilitation strategyrehabilitativerehabilitative therapyresponsesensorskillssocial rolesurgerysurgery painsurgical painsynergismtherapeutic targettherapy developmenttimelinetooltransmission processtraumatic brain damagetraumatic brain injury patientstreatment developmenttreatment strategytrigeminalμ opioid receptorsμ-ORμOR
Description preview
Traumatic brain injury (TBI), particularly mild TBI (mTBI, or “concussion”), is commonly associated with
chronic pain, such as headache and generalized body pain. It also leads to prolonged pain and worse
functional outcomes after subsequent injuries or surgeries, contributing to poor quality of life and opioid
misuse. Despite this well-known link…
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