grant
The role of notch modulation in spatially defined hematopoiesis
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAortaArteriesAutomobile DrivingBar CodesBiologyBloodBlood CellsBlood DiseasesBlood Precursor CellBlood Reticuloendothelial SystemCell BodyCell Communication and SignalingCell SignalingCellsDataData SetDevelopmentDifferentiation in cell cultureDown-RegulationEmbryoEmbryologyEmbryonicEndothelial CellsEndotheliumEnvironmentGene ExpressionGoalsHSC emergenceHSC productionHSC transplantationHematologic DiseasesHematological DiseaseHematological DisorderHematopoiesisHematopoieticHematopoietic Cell ProductionHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic Stem Cell TransplantHematopoietic Stem Cell TransplantationHematopoietic stem cellsHumanImmunofluorescenceImmunofluorescence ImmunologicIn VitroIn vitro cell differentiationIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLineage TracingLymphoidLymphopoiesisMapsMethodsMiceMice MammalsModern ManMolecularMurineMusNull MouseOutputPathway interactionsPeripheral Blood CellPlayPopulationPositionPositioning AttributePrevalenceProductionProtocolProtocols documentationRegenerative MedicineRegulationReporterRoleSignal TransductionSignal Transduction SystemsSignalingSiteSourceStem Cell DevelopmentStructure of umbilical arterySystemT-Cell DevelopmentT-Cell OntogenyT-Lymphocyte DevelopmentTestingTherapeuticTimeTranslatingUmbilical ArteriesUmbilical RegionUmbilicusadulthoodbarcodebiological signal transductionblood cell formationblood cell progenitorblood disorderblood progenitorblood stem cellblood stem cell emergenceblood stem cell transplantationblood treatmentblood-forming stem cellcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingconditional knock-outconditional knockoutdevelopmentaldifferentiation in culturedifferentiation in vitrodifferentiation of pluripotent stem cellsdifferentiation protocoldrivingemergence of hematopoietic stem cellsexperimentexperimental researchexperimental studyexperimentshematopoietic cell transplantationhematopoietic cellular transplantationhematopoietic differentiationhematopoietic progenitorhematopoietic progenitor cell transplantationhematopoietic stem cell emergencehematopoietic stem cell productionhematopoietic stem progenitor cellhemogenic endotheliumhemopoietichemopoietic progenitorhemopoietic stem cellhiPSChuman iPShuman iPSChuman induced pluripotent cellhuman induced pluripotent stem cellshuman inducible pluripotent stem cellshuman inducible stem cellsiPSiPSCiPSCsimprovedin vitro cellular differentiationin vivoinduced human pluripotent stem cellsinduced pluripotent cellinduced pluripotent stem cellinducible pluripotent cellinducible pluripotent stem cellinhibitorinsightinterestknock-downknockdownloss of functionlymphocytopoiesismethod developmentmouse modelmurine modelnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnotchnotch proteinnotch receptorsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyoverexpressoverexpressionpathwaypluripotent stem cell differentiationpreventpreventingprogenitor biologyprogenitor cell biologyprogenitor cell developmentprogenitor developmentprogramsreconstitutereconstitutionscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem and progenitor biologystem and progenitor cell developmentstem cell biologytreatment strategy
Description preview
Abstract
Hematopoietic stem cell (HSC) transplantation is a potent therapeutic strategy for the treatment of many blood
disorders. Therefore, the development of methods for deriving large quantities of HSCs is a major focus in
regenerative medicine. Unlike HSCs, human induced pluripotent stem cells (hiPSCs) can be grown indefinitely.
Despite…
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