grant
The role of neuronal activity on retinal angiogenesis and blood-retina barrier (BRB) maturation
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 1 May 2025Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AddressAffectAstrocytesAstrocytusAstrogliaBasement membraneBeta Cadherin-Associated ProteinBeta-1 CateninBlood VesselsBlood-Retinal BarrierBone-Derived Transforming Growth FactorCD31CUL-2CaveolaeCaveolasCell BodyCell Communication and SignalingCell CountCell DeathCell Growth in NumberCell MultiplicationCell NumberCell ProliferationCell SignalingCellsCellular ProliferationDataDefectDegenerative DisorderDegenerative Neurologic DisordersDevelopmentEndothelial CellsEndotheliumEnzyme GeneEnzymesEpistasisEpistatic DeviationEyeEyeballGLASTGLAST ProteinGeneralized GrowthGenetic EpistasisGenetic ModelsGliaGlial CellsGlnGlutamate Ammonia Ligase (ADP)Glutamate ReceptorGlutamate TranslocaseGlutamate Transport GlycoproteinGlutamate TransporterGlutamate-Ammonia LigaseGlutamate-Aspartate TransporterGlutamatesGlutamineGlutamine SynthetaseGrowthImpairmentInteraction DeviationIntracellular Communication and SignalingIschemiaKnowledgeKolliker's reticulumL-GlutamateL-GlutamineLigandsMeasuresMediatingMembrane Protein GeneMembrane ProteinsMembrane-Associated ProteinsMetabolicMiceMice MammalsMilk Growth FactorMouse StrainsMuller gliaMuller's cellMurineMusMutant Strains MiceMüller cellMüller gliaNerve CellsNerve DegenerationNerve Transmitter SubstancesNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeurotransmittersNon-neuronal cellNonneuronal cellOccluding JunctionsPECAM1PECAM1 genePRO2286Pathway interactionsPermeabilityPhasePhenotypePhotoreceptor CellPhotoreceptorsPhotosensitive CellPlatelet Transforming Growth FactorProcessQ LevoglutamideQ. LevoglutamideRetinaRetinal DiseasesRetinal DisorderRetinal Ganglion CellsRod PhotoreceptorsRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSurface ProteinsSynapsesSynapticTGF BTGF-betaTGF-βTGFbetaTGFβTestingTight JunctionsTissue GrowthTracerTranscriptTransducersTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneVEGFVEGFsVascular Endothelial Growth FactorsVisual ReceptorZonula Occludensangiogenesisastrocytic gliabeta catbeta cateninbiological signal transductioncholinergiccholinergic neurondegenerative conditiondegenerative diseasedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdevelopmentalearly onsetepistatic interactionepistatic relationshipexcitotoxicexcitotoxicityextracellulargene x gene interactiongenetic approachgenetic epistasesgenetic strategyglutamate signalingglutamate synthetaseglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalingglutamine synthaseinsightmouse mutantnecrocytosisnerve cementneuralneural degenerationneuro-vascular unitneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronalneuronal degenerationneurovascular unitnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynotchnotch proteinnotch receptorsnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenypathwaypharmacologicphotoactivationpostnatalresponseretina diseaseretina disorderretinal angiogenesisretinal ganglionretinal rodsretinopathyrod cellscRNA sequencingscRNA-seqsensorsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesynapsetranscriptomicsuptakevascularvascular componentvascular factorβ-catenin
Description preview
PROJECT SUMMARY
Reciprocal interactions among neuroglial and vascular components of the postnatal retina are critical for proper
angiogenesis and the establishment of the blood-retinal barrier (BRB). Although neuronal or glial cells-derived
signals that promote angiogenesis and BRB maturation are being elucidated, we still do not understand: a)…
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